Metformin Hydrochloride

This product is a hypoglycemic drug. This product can reduce fasting and postprandial hyperglycemia in patients with type 2 diabetes, and HbAlc can be reduced by 1% to 2%. The mechanism of this product in lowering blood sugar may be: 1. Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization. 2. Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc. 3. Inhibit hepatic gluconeogenesis and reduce hepatic glucose output. 4. Inhibit the uptake of glucose by intestinal wall cells. 5. Inhibit the biosynthesis and storage of cholesterol and reduce blood triglyceride and total cholesterol levels. Unlike the effect of insulin, this product has no effect on promoting fat synthesis and no obvious hypoglycemic effect on normal people. It generally does not cause hypoglycemia when used alone for type 2 diabetes.

Metformin Hydrochloride

It is used for patients with type 2 diabetes who are not satisfied with diet control alone, especially those who are obese and have hyperinsulinemia. This drug not only has the effect of lowering blood sugar, but also may reduce weight and hyperinsulinemia. It can be effective for patients with poor efficacy of certain sulfonylureas. For example, it is more effective when used in combination with sulfonylureas, intestinal glycosidase inhibitors or thiazolidinediones hypoglycemic drugs than when used alone. It can also be used for patients treated with insulin to reduce the amount of insulin.

1. Common symptoms include: nausea, vomiting, diarrhea, metallic taste in the mouth. 2. Sometimes there is weakness, tiredness, dizziness, and rash. 3. Although the incidence of lactic acidosis is very low, it should be paid attention to. Clinical manifestations include vomiting, abdominal pain, hyperventilation, mental disorder, and increased lactic acid concentration in the blood that cannot be explained by uremia, ketoacidosis or salicylic acid poisoning. 4. It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce megaloblastic anemia, and also cause malabsorption.

The following conditions should not be used: 1. Type 2 diabetes with ketoacidosis, liver and kidney dysfunction (serum creatinine exceeds 1.5mg/dl), pulmonary dysfunction, heart failure, acute myocardial infarction, severe infection and trauma, major surgery, and clinical hypotension and hypoxia. 2. Diabetes with severe chronic complications (such as diabetic nephropathy, diabetic fundus lesions). 3. Before intravenous pyelography or arterial angiography. 4. Alcoholics. 5. Patients with severe heart and lung diseases. 6. Patients with vitamin B12, folic acid and iron deficiency. 7. Patients with poor systemic condition (such as malnutrition, dehydration).

1. When used in combination with insulin, the hypoglycemic effect is enhanced, so the dosage should be adjusted. 2. This product can enhance the anticoagulant effect of anticoagulants (such as warfarin), which may cause bleeding tendency. 3. Cimetidine can increase the bioavailability of this product and reduce the renal clearance rate, so the dosage of this product should be reduced.

Keep sealed.

Tentatively 24 months.

Shandong Keyuan Pharmaceutical Co., Ltd.

• Founded in:

  2004-12-27

• Address:

  Keyuan Street, Shandong Shanghe Economic Development Zone, Jinan City, Shandong

• Tax NO.:

  91370126771003840T

• Registered Funds:

  108.29 million yuan

• Website:

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