Theophylline sustained-release tablets

This product has a direct relaxant effect on the smooth muscle of the respiratory tract. Its mechanism of action is relatively complex. In the past, it was believed that it was caused by inhibiting phosphodiesterase, thereby increasing the intracellular cAMP content. Recent experiments have shown that the bronchodilator effect of theophylline is partly due to the release of endogenous adrenaline and norepinephrine. In addition, theophylline is a purine receptor blocker that can counteract the contractile effect of adenine and other substances on the respiratory tract. Theophylline can enhance the contraction force of the diaphragm, especially when the diaphragm contraction is weak, so it is beneficial to improve respiratory function.

The main ingredients of this product and its chemical name are: The main ingredient of this product is theophylline, and its chemical name is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-hydrate. Its molecular formula is: (C7H8N4O2).H2O.

This product is white tablets.

It is suitable for relieving wheezing symptoms of bronchial asthma, wheezing bronchitis, obstructive pulmonary emphysema, etc.; it can also be used for wheezing during heart failure.

Oral administration. This product cannot be crushed or chewed. For adults or children over 12 years old, the starting dose is 0.1g~0.2g (1-2 tablets), twice a day, morning and evening with 100ml warm water. The dose is adjusted according to the condition and efficacy, but the daily dose does not exceed 0.9g (9 tablets), taken in 2 times.

The toxicity of theophylline often occurs when the serum concentration is 15-20mu;g/ml, especially at the beginning of treatment. Common symptoms in the early stage include nausea, vomiting, irritability, insomnia, etc. When the serum concentration exceeds 20mu;g/ml, tachycardia and arrhythmia may occur. When the theophylline content in the serum exceeds 40mu;g/ml, symptoms such as fever, dehydration, and convulsions may occur. In severe cases, respiratory and cardiac arrest may occur, leading to death.

It is contraindicated for patients who are allergic to this product, those with active peptic ulcers and uncontrolled convulsive diseases.

Precautions for children: The safety and effectiveness of taking this product every 24 hours for children under 12 years old has not been determined. Precautions for pregnancy and lactation: 1. Animal reproduction studies have not been conducted on theophylline, and it is not known whether theophylline can cause fetal damage or affect reproductive ability when taken by pregnant women. For pregnant women, xanthine drugs should only be given when necessary. 2. Theophylline can enter breast milk and cause irritability or other signs of poisoning in infants. It is recommended to stop breastfeeding or stop taking the drug. Precautions for the elderly: The elderly have a lower plasma clearance rate and increased potential toxicity. Patients over 55 years old should use it with caution.

1. Diltiazem and verapamil can interfere with the metabolism of theophylline in the liver. When used in combination with this product, the blood concentration and toxicity of this product will be increased. 2. Cimetidine can reduce the liver clearance rate of this product. When used in combination, it can increase the serum concentration and (or) toxicity of theophylline. 3. Certain antibacterial drugs, such as erythromycin, roxithromycin, clarithromycin of macrolides, enoxacin, ciprofloxacin, ofloxacin, levofloxacin, clindamycin, lincomycin of fluoroquinolones, etc., can reduce the clearance rate of theophylline and increase its blood concentration, especially erythromycin and enoxacin. When theophylline is used in combination with the above drugs, the dosage should be appropriately reduced. 4. Phenobarbital, phenytoin, and rifampicin can induce liver enzymes and accelerate the liver clearance rate of theophylline; theophylline also interferes with the absorption of phenytoin. The plasma concentrations of both are reduced. The dosage should be adjusted when used in combination. 5. When used in combination with lithium salts, the renal excretion of lithium can be increased. Affects the effect of lithium salts. 6. When used in combination with mexiletine, the clearance of theophylline can be reduced, the concentration of theophylline in plasma can be increased, and the dosage needs to be adjusted. 7. When used in combination with caffeine or other xanthine drugs, their effects and toxicity can be increased.

Keep away from light and store in sealed container.

0.1g (based on C7H8N402)

24 months

Hunan Shentaichun Pharmaceutical Co., Ltd.

• Founded in:

  2003-07-10

• Address:

  No. 75, Chenjiawan, Yanggutang, Yuhu District, Xiangtan City

• Tax NO.:

  91430300184687504P

• Registered Funds:

  26 million yuan

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