Cefathiamidine for injection

This product has antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria, and is particularly effective against Gram-positive cocci. The in vitro antibacterial activity test of this product shows that it has strong antibacterial activity against pneumococci, Streptococcus pyogenes, Staphylococcus aureus (MSSA strain), Staphylococcus epidermidis (MSSE strain) and Branhamella catarrhalis. The MIC90 for Streptococcus pneumoniae is 0.25mu;g/ml, the MIC90 for Streptococcus pyogenes is 0.5mu;g/ml, and the MIC90 for the other three bacteria is less than 8.0mu;g/ml. It also has strong antibacterial activity against Haemophilus influenzae, with a MIC90 of 2.0mu;g/ml. It has good antibacterial effects on viridans streptococci, hemolytic streptococci, non-hemolytic streptococci, diphtheria bacillus, perfringens, tetani bacillus and anthrax bacillus. The in vitro antibacterial activity against Staphylococcus aureus (MRSA strain) and Staphylococcus epidermidis (MRSE strain) is inferior to that of vancomycin. The mechanism of action of this product is to inhibit the cell wall synthesis of sensitive bacteria, thereby producing a bactericidal effect.

The main ingredient is: Cefathiamidine, chemical name: (6R, 7R)-3[(acetyloxy)methyl]-7-[-(N, N'-diisopropylamidinothio)-acetylamino]8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid betaine.

This product is white or off-white crystalline powder; almost odorless and hygroscopic.

Used for respiratory system, hepatobiliary system, ENT, urinary tract infections, endometritis and sepsis caused by sensitive bacteria.

Intramuscular injection: 0.5-1.0g per time, 4 times a day; children can take 50-100mg/kg per day according to their body weight, divided into 3-4 times. Intravenous drip: 2g per time, 2-4 times a day; children can take 50-100mg/kg per day according to their body weight, divided into 2-4 times. Dissolve the mixture in sterile water for injection or sodium chloride injection solution before use.

Occasionally, there may be urticaria, asthma, itchy skin, chills and high fever, angioedema, etc., and occasional increase in non-protein nitrogen and alanine aminotransferase after treatment.

It is contraindicated in patients who are allergic to cephalosporin antibiotics.

Precautions for children: Refer to the dosage. Precautions for pregnancy and lactation: Use with caution in early pregnancy. Although there have been no reports of problems with the use of cephalosporins in lactating women, their use still needs to weigh the pros and cons. Precautions for the elderly: Elderly patients have impaired renal function, so the dosage should be appropriately reduced when using.

After intramuscular injection of this product combined with probenecid 1g, the 12-hour urine excretion volume dropped to 65.7% of the administered dose.

Keep away from light, tightly closed, in a cool and dry place.

0.5 g

18 months

Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical General

• Founded in:

  1973-07-01

• Address:

  No. 88, Yunxiang Road, Tonghe Street, Baiyun District, Guangzhou

• Tax NO.:

  91440101714253245D

• Registered Funds:

  -

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