Cefathiamidine for injection

1. Pharmacology This product has antibacterial activity against Gram-positive bacteria and some negative bacteria, and is particularly effective against Gram-positive bacteria. The in vitro antibacterial activity test of this product shows that it has strong antibacterial activity against pneumococcus, Streptococcus pyogenes, Staphylococcus aureus (MSSA strain), Staphylococcus epidermidis (MSSE strain) and Branhamella catarrhalis. The MIC90 against Streptococcus pneumoniae is 0.25μg/ml, and the MIC90 against the other three bacteria is less than 8.0μg/ml. It also has strong antibacterial activity against Haemophilus influenzae, with a MIC90 of 2.0μg/ml. It has good antibacterial effect against viridans streptococci, hemolytic streptococci, non-hemolytic streptococci, diphtheria bacillus, perfringens, tetani bacillus and anthrax bacillus. The in vitro antibacterial activity against Staphylococcus aureus (MRSA strain) and Staphylococcus epidermidis (MRSE strain) is not as good as that of vancomycin. The mechanism of action of this product is to inhibit the cell wall synthesis of sensitive bacteria, thereby producing a bactericidal effect. 2. Toxicology The LD50 of this product for intravenous injection in mice is (1.02±0.04) g/kg, and the LD50 for intraperitoneal injection is (1.26±0.23) g/kg. In the reproductive toxicity test, the fetal mortality rate of mice in the test group was significantly higher than that in the control group (P<0.01).

The main ingredient of this product is cefathiamidine, and its chemical name is (6R,7R)-3-[(acetyloxy)methyl]-7-[α-(N,N-diisopropylamidinothio)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid betaine.

This product is white to slightly yellow crystalline powder; almost odorless and hygroscopic.

Used for respiratory system, hepatobiliary system, ENT, urinary tract infections, endocarditis and sepsis caused by sensitive bacteria.

Intramuscular injection: 0.5g~1.0g once, 4 times a day; children can take 50~100mg/kg per day according to their body weight, divided into 3~4 doses. Intravenous injection: 2g once, 2~4 times a day; children can take 50~100mg/kg per day according to their body weight, divided into 2~4 doses. Dissolve the mixture in sterile water for injection or sodium chloride injection solution before use.

The main adverse reactions are urticaria, asthma, skin itching, chills and high fever, angioneurotic edema, etc. Occasionally, blood urea nitrogen, alanine aminotransferase, and alkaline phosphatase increase after treatment. A small number of patients may experience neutropenia, Candida, Staphylococcus, etc. after medication.

Patients who are allergic to cephalosporin antibiotics or have a history of anaphylactic shock caused by penicillin are contraindicated.

Precautions for children: Not clear. Precautions for pregnancy and lactation: Use with caution in early pregnancy. Although there have been no reports of problems with the use of cephalosporins in lactating women, their use still needs to weigh the pros and cons. Precautions for the elderly: Elderly patients have reduced renal function, so the dosage should be appropriately reduced when using.

After intramuscular injection of this product combined with probenecid 1g, the 12-hour urine excretion volume dropped to 65.7% of the administered dose.

Sealed, stored in a cool, dark and dry place. Validity period: 24 months

1.0g

18 months

Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical General

• Founded in:

  1973-07-01

• Address:

  No. 88, Yunxiang Road, Tonghe Street, Baiyun District, Guangzhou

• Tax NO.:

  91440101714253245D

• Registered Funds:

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