Nitroglycerin tablets

The main pharmacological action is to relax vascular smooth muscle. Nitroglycerin releases nitric oxide (NO), which is the same as endothelial relaxing factor, activating guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in smooth muscle and other tissues, leading to dephosphorylation of myosin light chain, regulating the contractile state of smooth muscle, and causing vasodilation.

The main ingredient of this product is: nitroglycerin.

This product is white tablets.

It is used for the treatment and prevention of angina pectoris caused by coronary heart disease, and can also be used to lower blood pressure or treat congestive heart failure.

Tablets: Adults take 0.25-0.5 mg (1 tablet) sublingually at a time. Repeat 1 tablet every 5 minutes until the pain is relieved. If the pain persists after taking 3 tablets in 15 minutes, seek medical attention immediately. Use it preventively 5-10 minutes before activities or bowel movements to avoid inducing angina pectoris.

⑴ Headache: may occur immediately after medication, may be severe and persistent. ⑵ Dizziness, weakness, palpitations and other manifestations of postural hypotension may occur occasionally, especially in patients who are standing or immobilized. ⑶ Significant hypotension reactions may occur at therapeutic doses, manifested as nausea, vomiting, weakness, sweating, pallor and collapse. ⑷ Syncope, flushing, drug eruption and exfoliative dermatitis have all been reported.

It is contraindicated in patients with early myocardial infarction (severe hypotension and tachycardia), severe anemia, glaucoma, increased intracranial pressure, and known allergy to nitroglycerin. It is also contraindicated in patients using sildenafil citrate (Viagra), which enhances the antihypertensive effect of nitroglycerin.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: It is not known whether it will cause fetal damage or affect fertility, so it should only be used in pregnant women when it is necessary. It is also not known whether it is excreted from human breast milk, so lactating women should be cautious. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

⑴ When drinking moderately or excessively, the use of this drug may cause hypotension. ⑵ The combination with antihypertensive drugs or vasodilators can enhance the postural hypotensive effect of nitrates. ⑶ Aspirin can reduce the clearance of sublingual nitroglycerin and enhance its hemodynamic effects. ⑷ The use of long-acting nitrates can reduce the therapeutic effect of sublingual medication. ⑸ Sildenafil citrate (Viagra) enhances the antihypertensive effect of organic nitrates. ⑹ When used in combination with acetylcholine, histamine and sympathomimetic amines, the efficacy may be weakened.

Protect from light, seal tightly and store in a cool place.

0.5mg

36 months

Shandong XinYi Pharmaceutical Co., Ltd.

• Founded in:

  2013-04-09

• Address:

  No. 1 Xingping Road, Pingyuan County

• Tax NO.:

  91371426065926234K

• Registered Funds:

  177.40615851 million yuan

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