Nitroglycerin tablets

The main pharmacological action is to relax vascular smooth muscle. Nitroglycerin releases nitric oxide (NO), which is the same as endothelial relaxing factor, activates guanylate cyclase, increases cyclic guanosine monophosphate (cGMP) in smooth muscle and other tissues, leads to dephosphorylation of myosin light chain, regulates the contractile state of smooth muscle, and causes vasodilation. Nitroglycerin dilates the arteriovenous vascular bed, mainly dilating the veins, and its effect intensity is dose-related. Peripheral vein dilation causes blood to remain in the periphery, reducing the amount of blood returning to the heart and reducing left ventricular end-diastolic pressure (preload). Dilation of arteries reduces peripheral resistance (afterload). Arteriovenous dilation reduces myocardial oxygen consumption and relieves angina pectoris. It also has a dilating effect on epicardial coronary artery branches. Therapeutic doses can reduce systolic blood pressure, diastolic blood pressure, and mean arterial pressure, and effectively relax coronary arteries.

[Ingredients] The main ingredient of this product is nitroglycerin. Chemical name: glyceryl trinitrate Chemical structure: Molecular formula: C3H5N3O9 Molecular weight: 227.09

This product is white tablets.

It is used for the treatment and prevention of angina pectoris caused by coronary heart disease, and can also be used to lower blood pressure or treat congestive heart failure.

Tablets: Adults take 0.25-0.5 mg (1 tablet) sublingually at a time. Repeat 1 tablet every 5 minutes until the pain is relieved. If the pain persists after taking 3 tablets in 15 minutes, seek medical attention immediately. Use it prophylactically 5-10 minutes before activities or bowel movements to avoid inducing angina pectoris.

(1) Headache: may occur immediately after medication, may be severe and persistent. (2) Dizziness, weakness, palpitations and other manifestations of postural hypotension may occasionally occur, especially in patients who are standing or immobilized. (3) Significant hypotension reactions may occur at therapeutic doses, manifested as nausea, vomiting, weakness, sweating, pallor and collapse. (4) Syncope, flushing, drug rash and exfoliative dermatitis have all been reported.

It is contraindicated in patients with early myocardial infarction (with severe hypotension and tachycardia), severe anemia, glaucoma, increased intracranial pressure, and known allergy to nitroglycerin. It is also contraindicated in patients using sildenafil citrate (Viagra), which enhances the antihypertensive effect of nitroglycerin.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: It is not known whether it will cause fetal damage or affect fertility, so it should only be used in pregnant women when it is necessary. It is also not known whether it is excreted from human breast milk, so lactating women should be cautious. Precautions for the elderly: Not yet clear.

1. When drinking moderately or excessively, the use of this drug may cause hypotension. 2. Combination with antihypertensive drugs or vasodilators may enhance the postural hypotensive effect of nitrates. 3. Aspirin can reduce the clearance of sublingual nitric acid and glycerol and enhance its hemodynamic effects. 4. The use of long-acting nitrates may reduce the therapeutic effect of sublingual medications. 5. Sildenafil citrate (Viagra) enhances the antihypertensive effect of organic nitrates. 6. When used in combination with acetylcholine, histamine and sympathomimetic amines, the efficacy may be weakened.

Protect from light, seal tightly and store in a cool place.

0.5mg

36 months

Lesheng Pharmaceutical Shijiazhuang Co., Ltd.

• Founded in:

  2002-12-10

• Address:

  No. 198, Xiangjiang Road, Shijiazhuang High-tech Zone

• Tax NO.:

  9113010180441898XY

• Registered Funds:

  830,000 yuan

• Website:

  Log in to view

• Email:

  Log in to view