Pentoxifylline Injection

Pentoxifylline and its metabolites improve blood rheology by reducing blood viscosity. The exact mechanism of action has not yet been determined. Pentoxifylline has a dose-dependent effect of reducing blood viscosity, increasing red blood cell deformability, improving the blood rheological properties of white blood cells, and resisting the adhesion and activation of neutrophils. For patients with chronic peripheral arterial vascular disease, this product can increase blood flow, improve microcirculation and increase oxygen supply to tissues.

Pentoxifylline.

Cerebral blood circulation disorders such as transient ischemic attack, sequelae of stroke, brain dysfunction caused by cerebral ischemia; peripheral blood circulation disorders such as chronic thrombotic vasculitis, etc.

Intravenous drip. The patient should be in a supine position during use. The initial dose is 0.1g of pentoxifylline, which is infused within 2-3 hours. The maximum drip rate should not exceed 0.1g per hour. It can be increased by 0.05g each time according to the patient's tolerance, but the dosage should not exceed 0.2g each time. It should be taken 1-2 times a day, and the maximum daily dose should not exceed 0.4g.

1. Common adverse reactions include: nausea, dizziness, headache, anorexia, abdominal distension, vomiting, etc., with an incidence rate of more than 5%. 2. Less common adverse reactions include cardiovascular system: decreased blood pressure, irregular breathing, edema; nervous system: anxiety, depression, convulsions; digestive system: anorexia, constipation, dry mouth, thirst; skin: angioedema, rash, shiny nails; as well as blurred vision, conjunctivitis, enlarged central blind spot, decreased taste, increased saliva, leukopenia, muscle soreness, weight change, etc. 3. Occasional adverse reactions include angina pectoris, arrhythmia; jaundice, hepatitis, abnormal liver function, decreased blood fibrinogen, aplastic anemia, etc.

This product is contraindicated for patients who are allergic to pentoxifylline, patients with cerebral hemorrhage, extensive retinal hemorrhage, acute myocardial infarction, pregnant women, patients with severe coronary artery and cerebral vascular sclerosis and hypertension, severe arrhythmia and diabetes.

Precautions for children: Not recommended for children. Precautions for pregnancy and lactation: 1. Animal experiments suggest that long-term use of pentoxifylline increases the chance of fibroids, but there is no obvious teratogenicity. The pros and cons of using this drug should be considered for pregnant women; 2. Pentoxifylline and its metabolites can be secreted by breast milk, so lactating women should suspend the use of the drug. Precautions for the elderly: Elderly patients have slower metabolism in the liver, slower excretion through the kidneys and feces, and should reduce the dosage as appropriate.

1. When used in combination with antiplatelet or anticoagulant drugs, the coagulation time is prolonged. When used in combination with warfarin, the dose should be reduced; 2. When used in combination with theophylline drugs, there is a synergistic effect, which can increase the efficacy and toxicity of theophylline. Therefore, the doses of theophylline and pentoxifylline must be adjusted; 3. When used in combination with antihypertensive drugs, beta-receptor blockers, digitalis, diuretics, antidiabetic and antiarrhythmic drugs, there is no obvious cross-effect, but there is a slight aggravation and a decrease in blood pressure, so attention should be paid.

Keep in a light-proof and airtight container.

2ml:0.1g

Shaanxi Dunsi Pharmaceutical Co., Ltd.

• Founded in:

  2016-08-12

• Address:

  Xi'an Fengjing Industrial Park Standardized Factory Phase I Construction Area

• Tax NO.:

  91610125MA6TYKEJ97

• Registered Funds:

  96 million yuan

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