Metoprolol tartrate sustained-release tablets

This drug belongs to Class 2A, i.e., beta 1-receptor blockers without partial agonist activity (cardioselective beta 1-receptor blockers). It has a selective blocking effect on beta 1-receptors, no PAA (partial agonist activity), and no membrane stabilizing effect. Its effect on blocking beta 1 receptors is approximately equal to that of propranolol (PP), and its selectivity for beta 1 receptors is slightly inferior to that of atenolol. Metoprolol's effects on the heart, such as slowing heart rate, inhibiting cardiac contractility, reducing automaticity, and delaying atrioventricular conduction time, are similar to those of propranolol and atenolol (AT). Its effect on reducing elevated blood pressure and heart rate during exercise testing is also similar to that of PP and AT. Its contraction effect on vascular and bronchial smooth muscle is weaker than that of PP, so its effect on the respiratory tract is also smaller, but still stronger than that of AT. Metoprolol can also reduce plasma renin activity.

Metoprolol tartrate.

This product is a film-coated tablet, which appears white or off-white after the film coating is removed.

It is used to treat hypertension, angina pectoris, myocardial infarction, hypertrophic cardiomyopathy, aortic dissection, arrhythmia, hyperthyroidism, cardiac neurosis, etc. In recent years, it is also used to treat heart failure, and it should be used under the guidance of an experienced physician.

1. For the treatment of hypertension, 100-200 mg/time, twice a day, is equivalent to atenolol 100 mg/time, once a day. 2. For acute myocardial infarction, it is recommended to use it in the early stage, that is, within the first few hours, because immediate use can reduce the infarction range and reduce the short-term (15-day) mortality rate in patients who have not undergone thrombolysis (this effect appears 24 hours after medication). In patients who have already undergone thrombolysis, it can reduce the reinfarction rate and re-ischemia rate, and if the medication is used within 2 hours, it can also reduce the mortality rate. General usage: Metoprolol can be injected intravenously at 2.5-5 mg/time (within 2 minutes), once every 5 minutes, for a total of 3 times of 10-15 mg. After 15 minutes, start taking 25-50 mg orally, once every 6-12 hours, for a total of 24-48 hours, and then take 50-100 mg/time orally, twice a day. 3. For unstable angina pectoris, early use is also recommended, and the usage and dosage can refer to acute myocardial infarction. 4. If there are no contraindications in case of atrial fibrillation during acute myocardial infarction, metoprolol can be used intravenously, and the method is the same as above. 5. If there are no contraindications after myocardial infarction, it should be used for a long time, because it has been proven that doing so can reduce cardiac mortality, including sudden death. Generally 50-100 mg/time, twice a day. 6. In the treatment of hypertension, angina pectoris, arrhythmia, hypertrophic cardiomyopathy, hyperthyroidism, etc., generally 25-50 mg/time, 2-3 times a day, or 100 mg/time, twice a day. 7. For heart failure, this drug should be used on the basis of anti-heart failure treatment such as digitalis and/or diuretics. Initially 6.25 mg/time, 2-3 times a day, and then increase 6.25-12.5 mg/time, 2-3 times a day every few days to a week depending on the clinical situation. The maximum dose can be 50-100 mg/time, 2 times a day. The maximum dose should not exceed 300 mg-400 mg/day.

1. Cardiovascular system: slowed heart rate, conduction block, lowered blood pressure, worsening heart failure, cold limbs or untouchable pulse due to peripheral vascular spasm, Raynaud's sign. 2. Because of its fat solubility and easy penetration into the central nervous system, this system has more adverse reactions. Fatigue and dizziness account for 10%, depression accounts for 5%, and others include headache, dreaminess, insomnia, etc. Hallucinations are occasionally seen. 3. Digestive system: nausea, stomach pain, constipation <1%, diarrhea accounts for 5%, but it is not serious and rarely affects medication. 4. Others: shortness of breath, joint pain, itching, retroperitoneal fibrosis, deafness, eye pain, etc.

Significant bradycardia (heart rate <45/minute), cardiogenic shock, severe or acute heart failure, poor peripheral circulation perfusion, second-degree or third-degree atrioventricular block, sick sinus syndrome, and severe peripheral vascular disease.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: The use of beta-blockers during pregnancy can cause various problems in the fetus, including fetal growth retardation. Beta-blockers can have adverse effects on the fetus and newborn, especially bradycardia, so they should not be used during pregnancy or delivery. Precautions for the elderly: Not yet clear.

Co-administration with cimetidine or prior use of quinidine can increase the blood concentration of metoprolol.

Keep in a light-proof, sealed and dry place.

100mg

24 months

Jiangxi Nanchang Jisheng Pharmaceutical Co., Ltd.

• Founded in:

  1986-09-29

• Address:

  No. 666, Shizhen South Avenue, Traditional Chinese Medicine Science and Technology Innovation City, Ganjiang New District, Jiangxi Province

• Tax NO.:

  91360127158261497H

• Registered Funds:

  122.45 million yuan

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