Human prothrombin complex

This product contains four coagulation factors II, VII, IX, and X that are synthesized in the liver and depend on vitamin K. Vitamin K deficiency and severe liver disease can cause the deficiency of these four factors. And the deficiency of any of the above factors can lead to coagulation disorders. Infusion of this product can increase the concentration of coagulation factors II, VII, IX, and X in the blood.

Main components: coagulation factors II, VII, IX, and X.

This product is a white or gray-green loose body. After redissolution, it becomes a light yellow, light blue or yellow-green clear liquid.

It is used to treat congenital and acquired deficiency of coagulation factors II, VII, IX, and X. It is also used to treat hemophilia B, overdose of anticoagulants, vitamin K deficiency, coagulation disorder caused by liver disease, prolonged prothrombin time due to various reasons and patients who are planning to undergo surgery, and to treat bleeding symptoms in hemophilia A patients who have developed factor VIII inhibitors, and to reverse bleeding induced by coumarin anticoagulants.

Usage: 1. This product is for intravenous infusion only and should be used under the strict supervision of a clinical physician. 2. Before use, preheat this product and sterile water for injection or 5% glucose injection to 20-25°C, inject the preheated sterile water for injection or 5% glucose injection according to the amount indicated on the bottle label, and gently rotate until the product is completely dissolved (be careful not to produce a lot of foam). 3. It can be diluted to 50-100 ml with sodium chloride injection or 5% glucose injection, and then intravenously dripped with a blood transfusion device with a filter device. The drip speed should be slow at the beginning, and the drip speed should be slightly increased after 15 minutes. Generally, each bottle of 200 plasma equivalent units (PE) drips in about 30-60 minutes. 4. During the drip, the physician should pay attention to the use at any time. If clinical symptoms and signs of disseminated intravascular coagulation or thrombosis are found, the use should be stopped immediately. And heparin antagonism. Dosage: 1 The dosage varies with the degree of factor deficiency. Generally, 10 to 20 plasma equivalent units are infused per kg of body weight. After that, patients with factor VII deficiency should be infused every 6 to 8 hours, patients with factor IX deficiency should be infused every 24 hours, and patients with factor II and factor X deficiency should be infused every 24 to 48 hours. The dosage can be reduced or reduced as appropriate, and generally lasts for 2 to 3 days. 2 In cases of large bleeding or major surgery, the dosage can be appropriately increased according to the condition. 3 Patients with prolonged prothrombin time who are planning to undergo splenectomy should take the drug before surgery, and the decision should be made during and after surgery according to the condition.

Generally there are no adverse reactions. Rapid infusion may cause fever, flushing, headache and other side effects. The above symptoms will disappear if the infusion is slowed down or stopped.

There are no known contraindications when the indications are strictly controlled.

Do not use with other medicines.

Store below 8°C away from light.

300IU/bottle

Shanghai RAAS Blood Products Co., Ltd.

• Founded in:

  1988-10-29

• Address:

  No. 2009, Wangyuan Road, Fengxian District, Shanghai

• Tax NO.:

  913100006072419512

• Registered Funds:

  6,637,984,837 yuan

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