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Clodronate Disodium Injection

Function and Efficacy

This product is a bone metabolism regulator that can enter the hydroxyapatite crystals in the bone matrix. When osteoclasts dissolve the crystals, the drug is released, which can inhibit the activity of osteoclasts and indirectly inhibit bone resorption through osteoblasts.

Ingredients

Clodronate disodium.

Name Description Content CAS NO. Manufacturer
Clodronate disodium SaltIngredients

This product is a bone metabolism regulator that can enter the hydroxyapatite crystals in the bone matrix. When osteoclasts dissolve the crystals, the drug is released, which can inhibit the activity of osteoclasts and indirectly inhibit bone resorption through osteoblasts.

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22560-50-5 0

Indication

1. Hypercalcemia complicated by malignant tumors. 2. Bone pain caused by osteolytic cancer metastasis. 3. Can prevent or delay osteolytic bone metastasis of malignant tumors. 4. Various types of osteoporosis.

Usage and Dosage

1. Paget's disease: 300 mg/day, intravenous drip for more than 3 hours, for 5 days, then oral administration. 2. Hypercalcemia: 300 mg/day, intravenous drip for 3-5 days or 1.5 g intravenous drip once, then oral administration after blood calcium returns to normal.

Adverse Reactions

1. Dizziness and fatigue may occur in a few cases, but they usually disappear with continued treatment. 2. Adverse reactions such as increased serum lactate dehydrogenase and other liver enzyme levels, leukopenia, and abnormal renal function may sometimes occur.

Precautions

1. Patients who are allergic to this product are prohibited from using this product. 2. Patients with severe renal impairment and osteomalacia are prohibited from using this product.

Drug Interactions

Not yet clear

Storage

Sealed, store in a dry place.

Packaging Specification

5 ml: 300 mg

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