Norepinephrine bitartrate injection

This product is an adrenaline receptor agonist. It is a strong α receptor agonist and also stimulates β receptors. Through α receptor stimulation, it can cause extreme vasoconstriction, increase blood pressure, and increase coronary blood flow; through β receptor stimulation, it can strengthen myocardial contraction and increase cardiac output. When the dosage is 0.4μg/kg per minute, β receptor stimulation is the main effect; when a larger dose is used, α receptor stimulation is the main effect.

The main ingredient is: norepinephrine bitartrate, and its chemical name is: (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol bitartrate monohydrate.

This product is a colorless or almost colorless clear liquid; it easily deteriorates when exposed to light and air.

Used to treat hypotension caused by acute myocardial infarction, extracorporeal circulation, etc.; for shock, hypotension or hypotension after pheochromocytoma resection caused by insufficient blood volume, this product is used as an auxiliary treatment to supplement blood volume during emergency treatment to restore blood pressure and temporarily maintain brain and coronary artery perfusion until the blood volume supplementation treatment takes effect; it can also be used for hypotension during intrathecal blockade and blood pressure maintenance after cardiac arrest resuscitation.

Dilute with 5% glucose injection or glucose sodium chloride injection and drip intravenously. 1 Common dosage for adults: Start with a drip rate of 8-12μg per minute, and adjust the drip rate to achieve the ideal blood pressure level; the maintenance dose is 2-4μg per minute. If necessary, the above dose can be exceeded according to the doctor's instructions, but attention should be paid to maintaining or replenishing blood volume. 2 Common dosage for children: Start with a drip rate of 0.02-0.1μg/kg per minute according to body weight, and adjust the drip rate as needed.

1. Drug leakage may cause local tissue necrosis. 2. The strong vasoconstriction of this product can reduce blood flow to important organs. The sharp decrease in renal blood flow can reduce urine volume, and insufficient blood supply to tissues can lead to hypoxia and acidosis. When used for a long time or in large quantities, it can reduce venous return, increase peripheral vascular resistance, and reduce cardiac output, with serious consequences. 3. Reactions that should be taken seriously include whitening of the skin along the venous route during intravenous infusion, local skin breakdown at the injection site, cyanosis and redness of the skin, and severe dizziness. Although the above reactions are rare, the consequences are serious. 4. Some patients have rashes and facial edema due to allergies. 5. In patients with hypoxia, electrolyte imbalance, and organic heart disease

It is forbidden to use it in combination with halogenated anesthetics and other catecholamines. It is contraindicated in patients with cocaine poisoning and tachycardia.

Precautions for children: Children should be injected through a large vein and the injection site should be changed. No special problems have been found in its application so far. Precautions for pregnancy and lactation: Pregnant women should weigh the pros and cons and use with caution. Precautions for the elderly: Long-term or large-scale use by the elderly may reduce cardiac output.

When used with general anesthetics such as chloroform, cyclopropane, and halothane, the myocardium may be more sensitive to sympathomimetic amines, and ventricular arrhythmias may occur easily. They should not be used together. If they must be used together, the dosage should be reduced. 1 When used with beta-blockers, the efficacy of each is reduced. After beta-receptor blockade, the effect of alpha receptors is prominent, and hypertension and bradycardia may occur. 2 When used with antihypertensive drugs, it can offset or weaken the effect of antihypertensive drugs. When used with methyldopa, the pressor effect of this product is also enhanced. 3 When used with digitalis, it is easy to cause arrhythmias, and close attention should be paid to ECG monitoring. 4 When used with other sympathomimetic amines, the cardiovascular effect is enhanced. 5 When used with ergot preparations such as ergotamine, ergonovine, or oxytocin, vasoconstriction is enhanced, causing severe hypertension and bradycardia. 6. When used in combination with tricyclic antidepressants, the cardiovascular effects of this product may be enhanced by inhibiting tissue absorption of this product or enhancing the sensitivity of adrenaline receptors, causing arrhythmia, tachycardia, hypertension or hyperthermia. If it must be used in combination, the initial dosage of this product should be small and the cardiovascular effects should be monitored. 7. When used in combination with thyroid hormones, the effects of both are enhanced. 8. When used in combination with tolazoline, it may cause a drop in blood pressure, followed by an excessive rebound increase in blood pressure. Therefore, this product should not be used when tolazoline is overdosed.

Keep away from light, tightly closed, in a cool place.

1ml: 2mg

24 months