Cefixime Granules
Function and Efficacy
Cefixime is a third-generation oral cephalosporin that kills bacteria by inhibiting bacterial cell wall synthesis. It is stable to most beta-lactamases, and many strains producing penicillinase and cephalosporinase are still sensitive to this product. Cefixime has good antibacterial effects in vitro and in vivo against Gram-positive cocci such as pneumococci, Streptococcus pyogenes, and Gram-negative bacilli such as Haemophilus influenzae (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains), Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains). Cefixime also has antibacterial activity against Streptococcus pneumoniae, Parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia, Salmonella, Shigella, Serratia marcescens, Citrobacter heteromorphis, and Citrobacter malonate, but its clinical effectiveness has not yet been established. This product has poor antibacterial effect on Staphylococcus, and has no antibacterial effect on Pseudomonas aeruginosa, Enterobacter, Bacteroides fragilis, Clostridium, etc.
Ingredients
Cefixime.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| CefiximeIngredients |
The third generation of oral cephalosporins kills bacteria by inhibiting bacterial cell wall synthesis. They are stable to most beta-lactamases, and many strains producing penicillinase and cephalosporinase are still sensitive to them. They have good antibacterial effects on Gram-positive cocci such as pneumococci and Streptococcus pyogenes, and Gram-negative bacilli such as Haemophilus influenzae (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains), Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains). In vitro, they also have antibacterial activity against Streptococcus pneumoniae, Parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia, Salmonella, Shigella, Serratia marcescens, Citrobacter heteromorphis, and Citrobacter malonate, but their clinical effectiveness has not yet been established. They have poor antibacterial effects on Staphylococcus, and have no antibacterial effects on Pseudomonas aeruginosa, Enterobacter, Bacteroides fragilis, Clostridium, etc. More |
79350-37-1 | 49 |
Appearance
This product is a suspension granule with flavoring agent; it has a fragrant smell and sweet taste.
Indication
This product is suitable for the following bacterial infectious diseases caused by streptococci (except enterococci), pneumococci, gonococci, Branhamella catarrhalis, Escherichia coli, Klebsiella, Serratia, Proteus and influenza bacilli that are sensitive to cefixime: 1. Bronchitis, bronchiectasis (when infected), secondary infection of chronic respiratory system infections, pneumonia; 2. Pyelonephritis, cystitis, gonococcal urethritis; 3. Cholecystitis, cholangitis; 4. Scarlet fever; 5. Otitis media, sinusitis.
Usage and Dosage
Take with water. Dosage for adults and children weighing more than 30 kg: 100 mg (2 bags) each time, twice a day; for adults with severe infection, the dosage can be increased to 200 mg (4 bags) each time, twice a day. Children: 1.5-3.0 mg/kg each time, twice a day, or as directed by a doctor.
Adverse Reactions
Most of the adverse reactions of cefixime are short-lived and mild. The most common are gastrointestinal reactions, including diarrhea (16%), increased bowel movement (6%), abdominal pain (3%), nausea (7%), indigestion (3%), and abdominal distension (4%); adverse reactions with an incidence rate of less than 2% include rash, urticaria, drug fever, itching, headache, and dizziness. Laboratory abnormalities include transient increases in ALT, AST, ALP, LDH, bilirubin, BUN, and Cr, transient decreases in platelet and white blood cell counts and eosinophilia, and positive direct Coombs test.
Precautions
Patients with a history of allergy to this product or cephalosporin antibiotics are contraindicated.
Special Population Medication
Precautions for children: Use with caution in newborns and premature infants. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Reduce the dosage for elderly patients.
Drug Interactions
(1) This product is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin. Neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, other antihistamines such as diphenhydramine hydrochloride, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. Occasionally, it may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium. Prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. (2) The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. (4) Clavulanic acid can increase the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of B-lactamase.
Storage
Seal and store in a cool dark place (avoid light and not exceed 20℃).
Packaging Specification
0.1 g
Validity Period
30 months.
Manufacturer
Sinopharm ZHIJUN(Shenzhen)PHARMACEUTICAL Co., Ltd.
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Founded in:
1985-12-11 -
Address:
No. 16, Lanqing 1st Road, Guanlan High-tech Park, Longhua New District, Shenzhen -
Tax NO.:
91440300192190290M -
Registered Funds:
200 million yuan -
Website:
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Email: