Cefixime Granules

Cefixime is a third-generation oral cephalosporin that kills bacteria by inhibiting bacterial cell wall synthesis. It is stable to most β-lactamases, and many strains that produce penicillinase and cephalosporinase are still sensitive to this product. Cefixime has good antibacterial effects in vitro and in vivo against Gram-positive cocci such as pneumococci, Streptococcus pyogenes, and Gram-negative bacilli such as Haemophilus influenzae (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains), Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains). Cefixime also has antibacterial activity against Streptococcus pneumoniae, Parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia, Salmonella, Shigella, Serratia marcescens, Citrobacter heteromorphis, and Citrobacter malonate, but its clinical effectiveness has not yet been established. This product has poor antibacterial effect on Staphylococcus, and has no antibacterial effect on Pseudomonas aeruginosa, Enterobacter, Bacteroides fragilis, Clostridium, etc.

The active ingredient of this product is cefixime trihydrate.

This product is a suspension granule with flavoring agent; it has a fragrant smell and sweet taste.

This product is suitable for the following bacterial infectious diseases caused by streptococci (except enterococci), pneumococci, gonococci, Branhamella catarrhalis, Escherichia coli, Klebsiella, Serratia, Proteus and influenza bacilli that are sensitive to cefixime: 1. Bronchitis, bronchiectasis (when infected), secondary infection of chronic respiratory system infections, pneumonia; 2. Pyelonephritis, cystitis, gonococcal urethritis; 3. Cholecystitis, cholangitis; 4. Scarlet fever; 5. Otitis media, sinusitis.

Oral administration. Adults and children weighing more than 30 kg: 100 mg (2 bags) each time, twice a day; adults with severe infection can increase the dose to 200 mg (4 bags) each time, twice a day. Children: 1.5-3.0 mg/kg each time, twice a day, or as directed by a doctor.

Most of the adverse reactions of cefixime are short-lived and mild. The most common are gastrointestinal reactions, including diarrhea (16%), increased bowel movement (6%), abdominal pain (3%), nausea (7%), indigestion (3%), and abdominal distension (4%); adverse reactions with an incidence rate of less than 2% include rash, urticaria, drug fever, itching, headache, and dizziness. Laboratory abnormalities include transient increases in ALT, AST, ALP, LDH, bilirubin, BUN, and Cr, transient decreases in platelet and white blood cell counts and eosinophilia, and positive direct Coombs test.

Patients with a history of allergy to this product or cephalosporin antibiotics are contraindicated.

Precautions for children: The safety of the drug for premature infants and newborns has not been established (no experience). Precautions for pregnancy and lactation: The safety and effectiveness of this drug for pregnant women have not been established. Use this drug only when it is really necessary. It is not clear whether this drug is secreted from breast milk. If it is necessary to use it, breastfeeding should be suspended. Precautions for the elderly: Reduce the dosage of elderly patients.

(1) This product is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin. Neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, other antihistamines such as diphenhydramine hydrochloride, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. Occasionally, this product may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium. Prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. (2) The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. (4) Clavulanic acid can increase the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of B-lactamase.

Keep away from light, seal tightly and store in a cool dark place.

50mg (calculated as cefixime)

30 months.

Guangdong Hengjian Pharmaceutical Co., Ltd.

• Founded in:

  1994-02-23

• Address:

  No. 117, Longxi Road, Jiangmen City, Guangdong Province

• Tax NO.:

  91440704193959639D

• Registered Funds:

  16.98 million yuan

• Website:

  Log in to view

• Email:

  Log in to view