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Cefixime trihydrate

Cefixime trihydrate structure

CAS No:
125110-14-7
Formula:
C16H15N5O7S2.3H2O
Chemical Name:
Cefixime trihydrate
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-,hydrate (1:3),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-,trihydrate,[6R-[6α,7β(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-,trihydrate,(6R,7R)-;Cefixime trihydrate
Categories:
Analytical Chemistry > Standard

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Cefixime trihydrate Basic Attributes

Molecular Weight：

507.499

Exact Mass：

507.072968

HScode：

2941906000

Characteristics

PSA：

265.74000

XLogP3：

0.17230

Melting Point：

218-225℃

Water Solubility：

Soluble in water at 55.1 μg/mL

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

42/43

safety instructions：

22-36/37-45

RTECS Number：

XI0367200

Marks：

Precautionary statement(s)：

P261-P280-P342 + P311

Hazard Statements：

H317-H334

Drug Function and Efficacy

It has a wide range of antibacterial effects on both Gram-positive and Gram-negative bacteria, especially against Gram-positive bacteria such as Streptococcus and Pneumococcus, and Gram-negative bacteria such as Gonorrhea, Borrelia, Escherichia coli, Klebsiella, Serratia, Proteus, and Haemophilus influenzae. It also has excellent antibacterial activity against bacteria that produce β-lactamase. Its mechanism of action is to prevent the synthesis of bacterial cell walls.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefixime Capsules
Ingredients	The main ingredient of this product is: Cefixime trihydrate.
Indication	(1) This product is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin. Neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, other antihistamines such as diphenhydramine hydrochloride, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. Occasionally, this product may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium. Prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. (2) The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. (3) Clavulanic acid can increase the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of B-lactamase.
Specifications	50mg
Manufacturer	Hainan Rizhongtian Pharmaceutical Co., Ltd.

Cefixime Granules (Dalifen)
Ingredients	Cefixime trihydrate.
Indication	1. This product is contraindicated with the following drugs: Amikacin sulfate, gentamicin, kanamycin, tobramycin. Neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, other antihistamines such as diphenhydramine hydrochloride, lidocaine, norepinephrine, metaraminol, methylphenidate, succinylcholine, etc. Occasionally, it may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium. Prochlorperazine, B vitamins and vitamin C, hydrolyzed protein. 2. Furosemide, ethacrynic acid, bumetamol
Specifications	50 mg (sugar-free) based on 2 tablets of C16H15N507
Manufacturer	Sinopharm ZHIJUN(Shenzhen)PHARMACEUTICAL Co., Ltd.

Cefixime Granules
Ingredients	Cefixime trihydrate.
Specifications	50mg (calculated as C16H15N5O7S2)
Manufacturer	Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical General

See More Related Drugs

Registered Holders

Qilu Antibiotics Pharmaceutical Co., Ltd.

Japan
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