Cefuroxime Axetil Capsules

Cefuroxime axetil is a prodrug of cefuroxime. The mechanism of action of cefuroxime is to inhibit the synthesis of bacterial cell walls, so that bacteria cannot grow and reproduce. Cefuroxime has a broad-spectrum antibacterial effect, and has a strong antibacterial effect on Streptococcus pyogenes, Pneumococcus, Staphylococcus aureus methicillin-sensitive bacteria, Moraxella catarrhalis, Neisseria gonorrhoeae, and Haemophilus influenzae. It has a good effect on Enterobacteriaceae such as Escherichia coli, Klebsiella pneumoniae, and Proteus, but Pseudomonas aeruginosa and other Pseudomonas, Acinetobacter, and Enterococci are resistant.

Cefuroxime Axetil

This product is a hard capsule, and the content is off-white powder.

This product is suitable for acute pharyngitis or tonsillitis in adults, acute otitis media, maxillary sinusitis, acute exacerbation of chronic bronchitis, acute bronchitis, simple urinary tract infection, skin and soft tissue infection, and uncomplicated gonorrhea Neisseria urethritis and cervicitis caused by sensitive strains of Enterobacteriaceae such as hemolytic streptococci, Staphylococcus aureus (except methicillin-resistant strains), Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. It is also suitable for pharyngitis or tonsillitis, acute otitis media, and impetigo in children.

Oral administration, after meals. For adults, generally 0.25g each time, twice a day, and the general course of treatment is 5 to 10 days. In case of severe infection or suspected pneumonia, 0.5g each time, twice a day; for general urinary tract infection, 0.125g each time, twice a day; for patients with uncomplicated gonorrhea, the recommended dose is 1g, taken as a single dose. The general dosage for children is 0.125g each time, twice a day; for patients with otitis media under two years old, 0.125g each time, twice a day; for patients with otitis media over two years old, 0.25g each time, twice a day. For children over 12 years old, the dosage is the same as that for adults. For patients who have achieved a certain effect of injection of cefuroxime sodium and still need to continue treatment, this product can be switched to oral treatment. Or follow the doctor's advice.

As with other cephalosporins, rare adverse reactions include erythema polymorphum Stevens-Johnson syndrome, toxic epidermal necrolysis (eruptive epidermal necrolysis) and hypersensitivity reactions including rash, urticaria, pruritus, drug-induced fever, serum sickness and rare allergic reactions have also been reported. Some patients treated with cefuroxime axetil have experienced gastrointestinal disturbances, including diarrhea, nausea and vomiting. As with other broad-spectrum antibiotics, pseudomembranous colitis has also been reported. Cases of eosinophilia and transient ALT, AST, and LDH elevations have been reported during treatment with cefuroxime tablets; as with other cephalosporins, there have been rare reports of jaundice; and positive Coombs’ test reactions have been reported during cephalosporin therapy.

It is contraindicated in patients who are allergic to cephalosporin antibiotics.

Precautions for children: Not for use in children under 5 years old. Precautions for pregnancy and lactation: Use with caution in lactating women and pregnant women. Precautions for the elderly: Not yet clear.

Drugs that reduce gastric acid will reduce the bioavailability of this product.

Keep in a dark, sealed container and stored in a cool place. Validity period: two years

0.125 g (calculated as C16H16N408S)

24 months

Sinopharm ZHIJUN(Shenzhen)PHARMACEUTICAL Co., Ltd.

• Founded in:

  1985-12-11

• Address:

  No. 16, Lanqing 1st Road, Guanlan High-tech Park, Longhua New District, Shenzhen

• Tax NO.:

  91440300192190290M

• Registered Funds:

  200 million yuan

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