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Terfenadine Tablets

Function and Efficacy

This product is a specific H1 receptor blocker. At an effective antihistamine dose, this product and its metabolites are not easy to pass through the blood-brain barrier, so they rarely have central nervous system inhibitory effects.

Ingredients

The main ingredients of this product and its chemical name are: Terfenadine. Its chemical name is a-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxy-diphenylmethyl)-1-piperidinol. Molecular formula: C32H41NO2. Molecular weight: 471.69

Name Description Content CAS NO. Manufacturer
TerfenadineIngredients

This product is a specific H1 receptor blocker. At an effective antihistamine dose, this product and its metabolites are not easy to pass through the blood-brain barrier, so they rarely have central nervous system inhibitory effects.

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50679-08-8 18

Appearance

This product is white or off-white tablets.

Indication

For the treatment of seasonal and non-seasonal allergic rhinitis, urticaria and hay fever

Usage and Dosage

Usual adult dose: Oral, 30-60 mg at a time, twice a day.

Adverse Reactions

1 Cardiovascular system: According to foreign literature reports, the following adverse reactions are rare, such as ventricular arrhythmia, torsades de pointes, ventricular tachycardia, ventricular fibrillation, cardiac arrest, hypotension, atrial flutter, syncope, dizziness, QTc interval prolongation, etc. Most of the above reactions are caused by drug interactions; 2 Central nervous system: such as headache, dizziness, fatigue, etc.; 3 Gastrointestinal system: such as abdominal discomfort, nausea, vomiting, increased appetite, changes in bowel habits, etc.; 4 Others: such as dry mouth, dry nose, dry throat, rash, etc.

Precautions

1. Contraindicated in combination with certain azole antifungal drugs (such as ketoconazole, itraconazole, etc.), certain macrolide antibiotics (such as erythromycin, clarithromycin, oleandomycin, etc.) and other drugs that seriously damage liver function; 2. Contraindicated in patients with obvious liver damage; 3. Contraindicated in patients with organic heart disease, especially those with atrioventricular block and congenital QTc interval prolongation syndrome (Romano-Ward Syndrome); 4. Contraindicated in overdose; 5. Contraindicated in patients who are allergic to this product

Special Population Medication

Precautions for children: Suitable for children over 6 years old. Precautions for pregnancy and lactation: Use with caution for pregnant and lactating women. Precautions for the elderly: Use with caution.

Drug Interactions

Ketoconazole and itraconazole can inhibit the metabolism of this product, causing the drug to accumulate in the body and cause torsades de pointes. Other conazole drugs such as miconazole, fluconazole, metronidazole, erythromycin, clarithromycin and oleandomycin also have similar effects, which can cause death in severe cases.

Storage

Keep away from light and store in a sealed container.

Packaging Specification

60 mg

Validity Period

36 months

Manufacturer

Hubei KEYI Pharmaceutical Industry Co., Ltd.

  • Founded in:

    1997-05-23
  • Address:

    No. 8, Huanglongshan South Road, East Lake New Technology Development Zone, Wuhan
  • Tax NO.:

    91420000726103295U
  • Registered Funds:

    34.750206 million yuan
  • Email:

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