Anthraquinone ointment

The main pharmacological effects of anthralin include anti-epithelial cell proliferation, induction of epithelial cell differentiation and anti-inflammatory effects. Specifically, it blocks the pathological signal substances expressed by abnormal immune system in psoriasis by inhibiting the activity of protein kinase C in keratinocytes and polymorphonuclear leukocytes, inhibiting the secretion of interleukin-1, 6, 8 and tumor necrosis factor-a by human peripheral blood monocytes; and reduces the amount of transforming growth factor-a in keratinocytes and its affinity with epidermal growth factor receptors to produce anti-keratinocyte proliferation and anti-inflammatory effects. It can cause proliferation of mouse tail granular cells and downregulate the expression of transglutaminase (TGase) mRNA, indicating that it has the effect of inducing epithelial cell differentiation. It produces anti-inflammatory effects by inhibiting the production of reactive oxygen species by polymorphonuclear leukocytes induced by phorbol esters; but it can also stimulate normal polymorphonuclear leukocytes to produce reactive oxygen species and cause inflammatory stimulation of normal skin. Inhibit the lipoxygenase metabolic pathway, reduce the production of 5-lipoxygenase products 5-HETE and leukotriene B4 in stimulated human polymorphonuclear leukocytes; inhibit leukocyte chemotaxis; inactivate mitochondria and inhibit cell respiration; inhibit glucose-6-phosphatase activity. All of the above inhibitory effects can produce anti-inflammatory effects.

The main ingredients and chemical name of this product are: 1,8-dihydroxy-9-anthrone. Molecular formula: C14H10O3 Molecular weight: 226.23

This product is a yellow ointment.

Mainly used for plaque psoriasis vulgaris.

1. Concentration-increasing therapy: When starting treatment, use a low concentration for at least 5 days. After the skin has adapted, increase the concentration from 0.05%, 0.1%, 0.25%, 0.5%, 0.8%, 1.0% to 3%. Outpatients can be treated once a day, apply the medicine before going to bed, wash it off with soap the next morning, and apply moisturizer during the day to keep the skin lubricated. Inpatients can be treated twice a day, morning and evening, and a tar bath before each treatment can increase the efficacy. 2. Short-term contact therapy: After testing different concentrations and contact times, it was found that the optimal concentration and contact time were 3% concentration as the final dose, washed off after 20 minutes of action, and treated once a day; low-concentration, short-term contact therapy can also be used, that is, using 0.1% ointment for 5 to 20 minutes or using 1% ointment for 5 minutes and then washing it off with soap, both of which can produce sufficient anti-psoriasis activity with minimal side effects. Therefore, this therapy is more suitable for quiescent skin lesions. For large, persistent lesions, a higher concentration can be used for treatment. Initially, 1% ointment can be used once a day for 10 to 20 minutes and then washed off with soap. The duration can then be gradually extended to 30, 40, and 60 minutes until mild erythema appears. 3 Combination therapy: Anthraquinone can be used in combination with other drugs or therapies. The classic combination is the combination of anthraquinone and UVB or the combination of tar baths and UVB. Short-term contact therapy combined with UVB can significantly delay recurrence and reduce the symptoms of erythema irritation. Combined with tar, it is less irritating than anthraquinone alone and does not affect its anti-psoriatic activity. For thicker lesions, keratolytics can be used first, followed by anthraquinone. When the lesions subside, maintenance treatment should be considered.

The main adverse reactions are irritation to the skin, causing redness, burning, itching, etc. The nails can be dyed reddish brown and clothes can be stained yellow.

It is contraindicated for patients allergic to anthracene compounds and for patients with progressive pustular psoriasis.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

Combined use with corticosteroids can reduce the irritation of anthralin and shorten the clearance period of skin lesions. However, due to the high recurrence rate of corticosteroids and the rebound of pustular psoriasis, the combined use of anthralin and corticosteroids is still worth considering. Combined use with urea can increase drug transdermal penetration and reduce the concentration of anthralin, thereby reducing inflammatory stimulation to the skin. Salicylic acid can prevent anthralin from being oxidized to anthrone and has the effect of protecting anthralin. Alkaline amines can inactivate anthralin by promoting its oxidation. After short-term contact treatment, applying fat-soluble amines can inhibit the inflammatory response caused by anthralin remaining in the stratum corneum.

This product is very easy to oxidize and change color. The raw materials and preparations should be stored in a cool and airtight place away from light.

20g: 0.2g

24 months

Heilongjiang Tianchen Pharmaceutical Co., Ltd.

• Founded in:

  2015-10-26

• Address:

  No. 10, Weihai Road, Central Area, Haping Road, Harbin Economic Development Zone

• Tax NO.:

  91230199MA18W5274R

• Registered Funds:

  26 million yuan

• Email:

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