Ondansetron Hydrochloride Capsules

This product is a highly selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, that is, a new and powerful antiemetic. The mechanism of this drug in controlling nausea and vomiting is to antagonize the 5-HT3 receptors of peripheral and central neurons, thereby blocking the release of 5-hydroxytryptamine in the small intestine caused by factors such as chemotherapy and radiotherapy, and causing vomiting reflexes caused by the excitement of the vagal afferent nerves through the 5-HT3 receptors. This product has a highly efficient and selective effect, so it does not have the side effects of other antiemetics, such as extrapyramidal reactions and excessive sedation.

Ondansetron Hydrochloride

This product is a capsule, and the contents are white or off-white powder.

Used for vomiting caused by radiotherapy or cytotoxic chemotherapy.

1 For vomiting caused by highly emetic chemotherapy drugs: Adults: Ondansetron injection 8 mg intravenously 15 minutes before chemotherapy, 4 hours and 8 hours after chemotherapy, and oral Ondansetron capsule 8 mg every 8 hours after chemotherapy starts, for 5 consecutive days. Children: Before chemotherapy, the drug is injected intravenously at a dose of 5 mg/m2 of body surface area, and 12 hours later, 4 mg is taken orally. After chemotherapy, the drug should be given orally twice a day, 4 mg each time, for 5 consecutive days. 2 For vomiting caused by chemotherapy drugs that are not too emetic: Ondansetron injection 8 mg is injected intravenously 15 minutes before chemotherapy, and Ondansetron capsule 8 mg is taken orally every 8 hours thereafter, for 5 consecutive days. 3 For radiation

There may be headache, abdominal discomfort, constipation, and occasionally transient asymptomatic increase in transaminases. These reactions are mild and do not require special treatment.

1. Patients with gastrointestinal obstruction are prohibited from using this product. 2. Patients who are allergic to this product are prohibited from using this product.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: 1. Pregnant women should use with caution; 2. Lactating women should use with caution. If you use this product, you should stop breastfeeding. Precautions for the elderly: Not yet clear.

1. Evidence shows that this product can induce or inhibit the metabolism of other drugs taken at the same time. Special studies have shown that this product has no interaction with alcohol, temazepam, furosemide, tramadol and propofol; 2. Patients with poor metabolism of babutin and isoquine have no effect on the elimination half-life of this product. After repeated administration to such patients, the drug exposure level is no different from that of normal humans, so the dosage and frequency of medication do not need to be changed; 3. Combination with dexamethasone can enhance the antiemetic effect.

Keep in a dry place, sealed and protected from light. The validity period is tentatively three years.

8 mg (calculated as C18H19N30)

36 months

Sinopharm Zhijun (SHENZHEN) Pingshan Pharmaceutical Co., Ltd.

• Founded in:

  1990-07-13

• Address:

  No. 18, Qinglan 3rd Road, Pingshan New District, Shenzhen

• Tax NO.:

  91440300192194304B

• Registered Funds:

  50 million yuan

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