Theophylline Glucose Injection

This product is a complex of theophylline and ethylenediamine. Ethylenediamine can increase the water solubility of theophylline. Theophylline can relax bronchial smooth muscles and inhibit the release of allergic mediators from mast cells. While relieving spasms, it can also reduce bronchial congestion and edema, relieve bronchospasm caused by various reasons, and relax coronary arteries, peripheral blood vessels and bile duct smooth muscles; increase myocardial contractility and have a slight diuretic effect.

The main ingredient is theophylline, whose chemical name is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-hydrate.

It is suitable for relieving wheezing symptoms of bronchial asthma, asthmatic bronchitis, obstructive pulmonary emphysema, etc. It can also be used for acute heart failure and cardiac asthma.

For patients who have not recently received theophylline treatment, the first dose (loading dose) of intravenous drip is 4.7 mg/kg for adults or children based on body weight, and is administered slowly by intravenous drip (the infusion rate should not exceed 20 mg/minute, and the infusion time is generally not less than 30 minutes). The maintenance dose and infusion rate are shown in the following table: Intravenous drip of theophylline dose (acute bronchospasm) Group 12-hour maintenance reference dose Children aged 6 months to 9 years 0.95 mg/kg body weight/hour Children aged 9 to 16 years and young smokers 0.79 mg/kg body weight/hour Non-smoking adults 0.55 mg/kg body weight/hour Elderly patients and patients with cardiopulmonary diseases 0.47 mg/kg body weight/hour Congestive heart failure or liver failure 0.39 mg/kg body weight/hour When using conventional doses, if acute side effects occur, the drug should be stopped immediately for 5 to 10 minutes or the drug administration rate should be slowed down. Because the therapeutic index of theophylline is low and its metabolism varies greatly from person to person, the dosage should be individualized, and attention should be paid to observing the patient's response, lung function, and serum concentration of the drug. For the treatment of chronic diseases, the serum theophylline concentration after 3 days of medication should be 10-20 μg/ml.

1. Common adverse reactions include: nausea, stomach discomfort, vomiting, loss of appetite, headache, irritability, and irritability. 2. When intravenous drip is too fast or theophylline blood concentration exceeds 20 mu; g/ml, toxic reactions may occur, manifested as arrhythmia, increased heart rate, dizziness, a sharp drop in blood pressure, muscle tremors or epilepsy. Due to gastrointestinal irritation, bloody vomitus or tarry stools may be seen.

It is contraindicated for patients who are allergic to this product, patients with uncontrolled convulsive diseases, and patients with acute myocardial infarction accompanied by a significant decrease in blood pressure.

1 The combination of theophylline with ephedrine and other sympathomimetic amine bronchodilators increases efficacy but enhances toxicity. 2 The combination of theophylline with allopurinol (high dose), cimetidine, propranolol and oral contraceptives can reduce the clearance of theophylline and increase serum concentrations. 3 The combination of theophylline with rifampicin can reduce the serum concentration of theophylline. When theophylline is combined with phenytoin sodium, the serum concentrations of both drugs are reduced. 4 For patients who need theophylline, it is best to avoid the use of non-selective beta-receptor blockers (such as propranolol) because their pharmacological effects antagonize each other and the bronchodilator effect of this product may be inhibited. 5 The combination of alkali with barbiturates, carbamazepine and other hepatic microsomal enzyme inducers can accelerate the metabolism and clearance of theophylline. 6. When used in combination with clindamycin, lincomycin, certain macrolides (erythromycin, roxithromycin, clarithromycin), and quinolone antibiotics (enoxacin, ciprofloxacin), the clearance rate of this product in the liver can be reduced, the blood concentration can be increased, and even toxic reactions can occur. The dosage of this product should be adjusted before and after administration. 7. When used in combination with lithium salts, the excretion of lithium by the kidneys can be accelerated, and the latter's efficacy is reduced. 8. When used in combination with other theophylline drugs, adverse reactions may increase.

Keep away from light and store in a sealed container.

250ml: 0.2g

Shanghai Worldbest Anhui JINHUI Pharmaceutical Co., Ltd.

• Founded in:

  1989-11-27

• Address:

  No. 160 Lianhua Road, Yingzhou District, Fuyang City, Anhui Province

• Tax NO.:

  91341200151860120M

• Registered Funds:

  93 million yuan

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