Levamisole Hydrochloride Granules
Function and Efficacy
This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. target=_blank Levamisole also has immune regulation and immune excitation functions.
Ingredients
The chemical name of levamisole hydrochloride is (S)-(—)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Levamisole hydrochlorideIngredients |
Selectively inhibits succinate dehydrogenase in the insect's muscles, affects anaerobic metabolism, and reduces energy production; depolarizes the nerve muscles, causing continuous contraction and paralysis of the insect's muscles; its cholinergic effect is beneficial to the excretion of the insect; it may have an inhibitory effect on the microtubule structure of the insect; and it has immune regulation and immune excitation functions. More |
16595-80-5 | 7 |
Appearance
This product is colorful soluble granules with sweet taste.
Indication
It has good efficacy against ascaris, hookworm, pinworm and strongyloidiasis. Since the single dose of this product has a high efficacy, it is suitable for group treatment. It is more active than ethopropazine against adult worms and microfilariae of Bancroftian filariasis, Malayan Brugia and Onchocerca volvulus, but the long-term efficacy is poor.
Usage and Dosage
1. Ascaris: Oral, 1.5~2.5mg/kg for adults, taken on an empty stomach or before bedtime, 2~3mg/kg for children. 2. Hookworm: Oral, 1.5~2.5mg/kg, once a night, for 3 consecutive days. 3. Treatment of filariasis: 4~6mg/kg, divided into 2~3 doses, for 3 consecutive days.
Adverse Reactions
Generally mild. Nausea, vomiting, abdominal pain, etc., a few may have taste disorders, fatigue, dizziness, headache, joint pain, confusion, insomnia, fever, flu-like symptoms, hypotension, vasculitis, rash, photosensitive dermatitis, etc., proteinuria, individual granulocytopenia, thrombocytopenia, a few even have agranulocytosis (usually reversible), often in patients with rheumatism or tumors. In addition, it can cause immediate and Arthus allergic reactions, which may be atopic reactions caused by stimulating T cells. Individual cases may have ataxia, paresthesia or blurred vision.
Precautions
It is contraindicated in patients with impaired liver and kidney function, active hepatitis, early pregnancy, or pre-existing schistosomiasis.
Special Population Medication
Precautions for children: follow doctor's advice. Precautions for pregnancy and lactation: follow doctor's advice. Precautions for the elderly: follow doctor's advice.
Drug Interactions
1. Combined with pyrantel, it can treat severe hookworm infection and improve the effect of expelling American hookworm. 2. Combined with thiabendazole, it can treat mixed intestinal nematode infection. 3. Sequential use with diethylcarbamazine citrate can treat filarial infection. 4. It should not be used in combination with tetrachloroethylene to avoid increasing its toxicity.
Storage
Sealed, store in a cool and dry place
Packaging Specification
10 g: 50 mg
Validity Period
24 months