Megestrol acetate capsules

This product is a semi-synthetic progesterone derivative, which has a certain inhibitory effect on hormone-dependent tumors. Its mechanism of action is the same as that of medroxyprogesterone, which may be through the influence on the secretion of pituitary gonadotropin, controlling the development and growth of ovarian follicles, thereby reducing the production of estrogen. It acts on estrogen receptors, preventing their synthesis and reuse, interfering with their binding with estrogen, and inhibiting tumor cell growth. In addition, it can also antagonize glucocorticoid receptors and interfere with the interaction between steroid hormone receptors and regulatory proteins related to cell growth and differentiation.

The chemical name of this product is: 6-methyl-17alpha;-hydroxypregnane-4,6-diene-3,20-dione 17-acetate. Its structural formula is: Molecular formula: C24H32O4, molecular weight: 384.52.

This product is a capsule, and the contents are white granules.

It is mainly used to treat advanced breast cancer and advanced endometrial cancer, and also has a certain effect on kidney cancer, prostate cancer and ovarian cancer. It can also improve the appetite and cachexia of patients with advanced tumors.

Normal dose: 160 mg each time, orally, once a day. High dose: 160 mg each time, orally, 2 to 4 times a day.

Similar to other progesterone drugs, but generally milder. Weight gain is a common adverse reaction of this product, which is caused by an increase in body fat and body cell volume, and is not necessarily accompanied by fluid retention. For patients with advanced cancer cachexia and weight loss, this side effect is often beneficial. Thromboembolic phenomena have been rarely reported, including thrombophlebitis and pulmonary embolism. Other reactions can cause breast pain, galactorrhea, vaginal bleeding, menstrual disorders, and facial flushing. There are also adrenal cortisol effects, moon face, hypertension, and hyperglycemia. The incidence of uterine bleeding is 1-2%. Nausea and vomiting are occasionally seen, and reactions such as dyspnea, heart failure, and rash are rare.

This product is contraindicated for patients who are allergic to it. It is contraindicated for patients with severe thrombophlebitis, thromboembolic diseases, severe liver damage and hypercalcemia caused by bone metastasis.

Not yet clear.

Keep in a light-proof and airtight container.

80 mg

Jiangsu Nhwa Pharmaceutical Co., Ltd.

• Founded in:

  1999-03-29

• Address:

  No. 18, Yangshan Road, Xuzhou Economic and Technological Development Zone

• Tax NO.:

  913203001363846728

• Registered Funds:

  1016.176792 million yuan

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