Doxepin hydrochloride cream

Pharmacology: This product has the effect of blocking H1 and H2 receptors. It is also a cholinergic receptor and adrenergic receptor antagonist. Its H1 receptor blocking potency is 775 times stronger than diphenhydramine, 56 times stronger than antalol, and 11 times stronger than cyproheptadine. The skin administration of 117mg/kg, 83mg/kg, and 50mg/kg of this product has a significant inhibitory effect on the systemic pruritus of mice caused by dextran, and has a significant reducing effect on the skin vascular permeability of mice. It is stronger than diphenhydramine and inhibits the allergic reaction of guinea pigs caused by histamine phosphate. The anti-allergic effect on the three allergic models shows a good dose-effect relationship. Toxicology: This product produces moderate irritation to intact and damaged skin, but it can be completely recovered after stopping the drug for one week. Mouse (oral) LD50 148 ~ 178mg/kg, rat 346 ~ 460mg/kg.

The main ingredients of this product and their chemical names: N,N-dimethyl-3-dibenzo(b,e)-oxepin-11(6H)ylidene-1-propylamine hydrochloride.

This product is a white cream with an emulsion base.

Used for chronic simple lichen planus, localized pruritus, itching caused by acute and chronic eczema and atopic dermatitis.

Apply externally to the affected area, 2 to 3 times a day.

1. General adverse reactions include drowsiness, dry mouth, headache, dizziness, fatigue, mood changes, taste changes, nausea, anxiety and fever. 2. Local adverse reactions include transient tingling and/or burning sensation, itching, erythema, dry skin, etc. [Contraindications] 1. Because this product has anticholinergic effects and can be detected in the blood after external use, it is contraindicated for patients with untreated narrow-angle glaucoma or a tendency to urinary retention, heart failure, severe liver and kidney damage, and a history of epilepsy. 3. It is contraindicated for patients with a history of severe drug allergies.

1 Because this product has anticholinergic effects and can be detected in the blood after external use, it is contraindicated for patients with untreated narrow-angle glaucoma or a tendency to urinary retention, heart failure, severe liver and kidney damage, and a history of epilepsy. 2 It is contraindicated for patients with a history of severe drug allergies.

Precautions for children: This product is contraindicated for children. Precautions for pregnancy and lactation: This product is contraindicated for pregnant and lactating women. Precautions for the elderly: This product should be used with caution in elderly patients.

There are different degrees of interactions with monoamine oxidase inhibitors, tricyclic antidepressants, cimetidine, ethanol, etc.

Seal tightly and store in a cool place.

l0g:0.5g

24 months

Hubei KEYI Pharmaceutical Industry Co., Ltd.

• Founded in:

  1997-05-23

• Address:

  No. 8, Huanglongshan South Road, East Lake New Technology Development Zone, Wuhan

• Tax NO.:

  91420000726103295U

• Registered Funds:

  34.750206 million yuan

• Email:

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