Nedaplatin for injection

The main ingredient of this product is nedaplatin.

It is mainly used for solid tumors such as head and neck cancer, non-small cell lung cancer, and esophageal cancer.

Before use, dissolve it with normal saline, dilute it to 500ml, and drip it intravenously. The drip time should not be less than 1 hour. After the drip is finished, continue to drip more than 1000ml. The recommended dose is 80-100mg/m2 per administration, once per course of treatment, and the next course of treatment can be carried out after an interval of 3-4 weeks.

The main adverse reaction of this product is bone marrow suppression, which is manifested by a decrease in white blood cells, platelets, and hemoglobin; other common adverse reactions include digestive tract symptoms such as nausea, vomiting, loss of appetite, as well as abnormal liver and kidney function, ototoxicity, and hair loss. Although the incidence of other adverse reactions is low, they should be of concern: Severe adverse reactions: 1) Symptoms of anaphylactic shock (0.1-5%): If symptoms of anaphylactic shock (flush, dyspnea, chills, decreased blood pressure, etc.) occur, you should observe carefully, and if abnormalities are found, stop the drug immediately and take appropriate measures. 2) Bone marrow suppression (frequency unknown): manifested by erythropenia, anemia, leukopenia, neutropenia, thrombocytopenia, and bleeding tendency (0.

The following patients are contraindicated: 1. Those with obvious bone marrow suppression and severe liver and kidney dysfunction. 2. Those who are allergic to other platinum preparations and dextran. 3. Pregnant women, those who may become pregnant, and those with severe complications.

Precautions for children: The safety of this product for children has not been established. Precautions for pregnancy and lactation: 1. Animal experiments have observed that this product has teratogenic and fetal death effects, so pregnant women and patients who may become pregnant are prohibited from using this product. 2. It has been reported that similar drugs such as cisplatin can be secreted through breast milk, so breastfeeding women should stop breastfeeding when taking this drug. Precautions for the elderly: 1. This product is mainly excreted through the kidneys. Since the renal function of the elderly is generally impaired and the excretion is delayed, the possibility of bone marrow suppression should be observed. 2. The recommended initial dose for elderly patients is 80 mg/m2.

1. When this product is used in combination with other anti-tumor drugs (such as alkylating agents, antimetabolites, anti-tumor antibiotics, etc.) and radiotherapy, the bone marrow suppression effect may be enhanced. 2. When used in combination with aminoglycoside antibiotics and vancomycin hydrochloride, the damage to renal function and hearing organs may increase.

20mg

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

• Founded in:

  2003-01-14

• Address:

  No. 699, Kejian Road, Jiangning Science Park, Nanjing

• Tax NO.:

  91320100745398965U

• Registered Funds:

  768 million yuan

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