Nedaplatin
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Nedaplatin
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CAS No:
95734-82-0
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Formula:
C2H8N2O3Pt
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Chemical Name:
Nedaplatin
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Synonyms:
Platinum,diammine[2-(hydroxy-κO)acetato(2-)-κO]-,(SP-4-3)-;Platinum,diammine[hydroxyacetato(2-)-O1,O2]-,(SP-4-3)-;Platinum,diammine[(hydroxy-κO)acetato(2-)-κO]-,(SP-4-3)-;Acetic acid,hydroxy-,platinum complex;(SP-4-3)-Diammine[2-(hydroxy-κO)acetato(2-)-κO]platinum;254S;S 254;Nedaplatin;NSC 375101;Aqupla
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CAS No:
Description
Nedaplatin is a derivative of cisplatin and DNA damage agent.Target: OthersNedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of NDP at microgram/milliliter concentrations [1]. NDP was developed as a se
Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
(glycolato-O,O')diammineplatinum II
Computed Properties
Molecular Weight:303.18
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Exact Mass:303.018286
Monoisotopic Mass:303.018286
Topological Polar Surface Area:59.5
Heavy Atom Count:8
Complexity:50.5
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
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Qilu Pharmaceutical Co., Ltd.
Active
China
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Simcere Pharmaceutical Co., Ltd.
Active
China
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Nanjing Hairun Pharmaceutical Co., Ltd.
Active
China
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