Calcium Folinate and Sodium Chloride Injection

Pharmacological action: This product is a formylated derivative of the reduced form of folic acid, which is the activated form of folic acid in the body. Folic acid is reduced and methylated by dihydrofolate reductase in the small intestinal cells, converted into methyltetrahydrofolate, and then participates in the synthesis of purine and pyrimidine nucleotides and the conversion of certain amino acids in the body as a coenzyme. Methotrexate can bind to dihydrofolate reductase, blocking the conversion of dihydrofolate into tetrahydrofolate, thereby inhibiting the synthesis of thymine nucleotides, DNA, RNA and even protein. After entering the body, this product is converted into tetrahydrofolate by tetrahydrofolate reductase, which can limit the degree of damage to normal cells caused by methotrexate and reverse the reaction of methotrexate to the bone marrow and gastrointestinal mucosa, but it has no obvious effect on the neurotoxicity caused by methotrexate that has already occurred.

Calcium folinate

This product is a colorless to light yellowish green clear liquid.

Used in combination with 5-fluorouracil for the treatment of advanced colon and rectal cancer.

Used in combination with 5-Fu, the general dose is 5-Fu 370mg/m2 slow intravenous drip and calcium folinate 200mg/m2 intravenous drip.

Rarely, allergic reactions such as rash, hives, or asthma may occur occasionally.

It is contraindicated in pernicious anemia and megaloblastic anemia caused by vitamin B12 deficiency.

Precautions for children: Children taking anti-epileptic drugs should use this product with caution (see Drug Interactions). Precautions for pregnancy and lactation: Although animal studies have not shown that this product has reproductive toxicity, animal experiments cannot accurately predict human responses. Since calcium folinate has not been properly and adequately controlled clinical studies in pregnant women, this product should not be used during pregnancy unless absolutely necessary. It is not clear whether this product is secreted in human milk, and lactating women should use this product with caution.

Large amounts of folic acid may counteract the anti-epileptic effects of phenobarbital, phenytoin sodium, and primidone, increasing the rate of epileptic seizures in some children who are taking anti-epileptic drugs. Preliminary studies in animals and humans have shown that a small amount of folinic acid enters the spinal cord in the form of 5-methylfolate when administered systemically, causing a decrease in the usual blood concentration of methotrexate after intrathecal administration. Therefore, high doses of folinic acid may reduce the effect of intrathecal administration of methotrexate. Folinic acid may increase the toxicity of fluorouracil. This product can be used simultaneously with pyrimethamine or trimethoprim to prevent the latter from causing secondary megaloblastic anemia.

Keep in a dark, sealed and cool place. The validity period is tentatively set at one year.

100ml: 0.2g calcium folinate and 0.9g sodium chloride

12 months