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Calciumfolinatc

Calciumfolinatc structure

CAS No:
6035-45-6
Formula:
C20H21CaN7O7
Chemical Name:
Calciumfolinatc
Synonyms:
Folaren;Foliben;Folidan;NSC-3590;Calcium folinatc;Folinic acid calcium salt;Leucovorin calcium pentahydrate;FOLINIC ACID(SEE CALCIUM FOLINATE);CALCIUM FOLINATE(FOLINIC ACID)(RG);FOLINIC ACID CALCIUM CELL CULTURE TESTED
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

Description

Folinic Acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.Target: Folate analogApproved: 2008Folinic acid (calcium salt pentahydrate) is the calcium salt form of folinic acid, which is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other a

Calciumfolinatc Basic Attributes

Molecular Weight：

511.5

Exact Mass：

601.16566

DSSTox ID：

DTXSID3036999

HScode：

2942000000

Characteristics

PSA：

226

Appearance：

Yellow-white to yellow powder

Melting Point：

240-250°C

Storage Conditions：

Store at RT.

Specific rotation：

D21 +14.9° (c = 1 in water)

Safety Information

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

26-36

Marks：

GHS Classification：

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Calciumfolinatc Use and Manufacturing

Antianemic

Computed Properties

Molecular Weight:601.6
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:8
Exact Mass:601.1656603
Monoisotopic Mass:601.1656603
Topological Polar Surface Area:231
Heavy Atom Count:40
Complexity:743
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:7
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a formylated derivative of the reduced form of folic acid, which is the activated form of folic acid in the body. It can directly provide the activated form of folic acid in the body, which can rescue the toxic reaction of excessive folic acid antagonists in the body, and is beneficial to the synthesis of thymine nucleotides, DNA, RNA and even proteins. It can limit the degree of damage of methotrexate to normal cells, and through mutual competition, it can reverse the reaction of methotrexate to the bone marrow and gastrointestinal mucosa, but it has no effect on the existing methotrexate neurotoxicity.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Calcium folinate for injection
Ingredients	The main ingredient and its chemical name are: Calcium folinate. The chemical name is: 5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid calcium salt. Its structural formula is: Molecular formula: C20H21CaN7O7bull;5H2O Molecular weight: 601.61.
Indication	The use of this product in large doses together with barbiturates, primidone or phenytoin sodium may affect the anti-epileptic effect.
Specifications	Calculated as C20H23N7O7 25mg
Manufacturer	Beijing SL Pharmaceutical Co., Ltd.

Calcium folinate for injection
Ingredients	The main ingredients of this product and its chemical name are: Calcium folinate. Chemical name: 5-methyl-5,6,7,28-tetrahydropteroyl-L-monoglutamic acid calcium salt.
Indication	Large amounts of folic acid may counteract the anti-epileptic effects of phenobarbital, phenytoin and primidone, increasing the rate of epileptic seizures in some children who are taking anti-epileptic drugs. Preliminary studies in animals and humans have shown that a small amount of folinic acid enters the spinal cord in the form of 5-methylfolate when administered systemically, causing a decrease in the usual blood concentration of methotrexate after intrathecal administration. Therefore, high doses of folinic acid may reduce the effect of intrathecal administration of methotrexate. Folinic acid may increase the toxicity of fluorouracil. This product can be used simultaneously with pyrimethamine or trimethoprim to prevent the latter from causing secondary megaloblastic anemia.
Specifications	300mg
Manufacturer	Shanxi Zhendong Taisheng Pharmaceutical Co., Ltd.

Calcium folinate for injection
Ingredients	The main ingredients and chemical names of this product are: Calcium folinate. Chemical name: 5-methyl-5,6,7,16-tetrahydropteroyl-L-monoglutamic acid calcium salt.
Indication	Large amounts of folic acid may counteract the anti-epileptic effects of phenobarbital, phenytoin and primidone, increasing the rate of epileptic seizures in some children who are taking anti-epileptic drugs. Preliminary studies in animals and humans have shown that a small amount of folinic acid enters the spinal cord in the form of 5-methylfolate when administered systemically, causing a decrease in the usual blood concentration of methotrexate after intrathecal administration. Therefore, high doses of folinic acid may reduce the effect of intrathecal administration of methotrexate. Folinic acid may increase the toxicity of fluorouracil. This product can be used simultaneously with pyrimethamine or trimethoprim to prevent the latter from causing secondary megaloblastic anemia.
Specifications	100mg (as folinic acid)
Manufacturer	Shenzhen Neptunus Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Ppd Pharmaceutical Development (Beijing) Co., Ltd.

China
Active
Zhejiang Davi Pharmaceutical Co., Ltd.

China
Active
Huzhou Zhanwang Pharmaceutical Co., Ltd.

China
Active

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