Potassium Chloride for Injection

Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions, and the serum potassium concentration is only 3.5-5.0 mmol/L. The body mainly relies on Na+-K+ ATPase on the cell membrane to maintain the difference in K+ and Na+ concentrations inside and outside cells. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H+ enters the cell. In order to maintain the potential difference inside and outside the cell, K+ is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside cells are closely related to certain functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity of nerves and muscles including myocardium, etc.

The main ingredient of this product and its chemical name: potassium chloride.

This product is a colorless clear liquid.

1. Treat hypokalemia caused by various reasons, such as insufficient food intake, vomiting, severe diarrhea, use of potassium-excreting diuretics, hypokalemic familial periodic paralysis, long-term use of glucocorticoids and hypokalemia caused by supplementation of hypertonic glucose, etc. 2. Prevent hypokalemia. When patients have potassium loss, especially if hypokalemia is harmful to patients (such as patients using digitalis drugs), preventive potassium salt supplementation is required, such as eating very little, severe or chronic diarrhea, long-term use of adrenocortical hormones, potassium-losing nephropathy, Bartter syndrome, etc. 3. Frequent, multifocal premature beats or rapid arrhythmias caused by digitalis poisoning.

It is used for patients with severe hypokalemia or those who cannot take it orally. The general usage is to add 10-15ml of 10% potassium chloride injection to 500ml of 5% glucose injection and drip it (avoid direct intravenous drip and push injection). The dose, concentration and speed of potassium supplementation are determined according to the clinical condition, blood potassium concentration and improvement of electrocardiogram potassium deficiency pattern. The potassium concentration should not exceed 3.4g/L (45mmol/L), the potassium supplementation speed should not exceed 0.75g/hour (10mmol/hour), and the daily potassium supplementation amount is 3-4.5g (40-60mmol). When potassium deficiency in the body causes severe rapid ventricular ectopic arrhythmias, such as torsades de pointes, short bursts, recurrent multi-line ventricular tachycardia, ventricular flutter and other life-threatening severe arrhythmias, the potassium salt concentration should be high (0.5%, even 1%), the drip rate should be fast, 1.5g/hour (20mmol/hour), and the potassium supplementation amount can reach 10g or more per day. If the condition is critical, the potassium concentration and speed can exceed the above regulations. However, it is necessary to closely monitor the blood potassium and electrocardiogram to prevent the occurrence of hyperkalemia. The daily dose for children is calculated based on 0.22g/kg (3mmol/kg) of body weight or 3g/m2 of body surface area.

1. When the intravenous drip concentration is high, the speed is fast or the vein is thin, it is easy to stimulate the venous lining and cause pain. 2. When the drip speed is fast or there is original renal damage, attention should be paid to the occurrence of hyperkalemia. Once hyperkalemia occurs, it should be treated urgently.

1. Patients with hyperkalemia. 2. Patients with acute renal insufficiency or chronic renal insufficiency are contraindicated.

Precautions for children: See other items below, or follow doctor's advice. Precautions for pregnancy and lactation: There is no research data on the safety of this product for pregnant and lactating women.

1. Adrenal glucocorticoids, especially those with more obvious mineralocorticoid effects, adrenal mineralocorticoids and adrenocorticotropic hormone (ACTH), can promote urinary potassium excretion, and when used in combination with this product, the efficacy of potassium salts is reduced. 2. Anticholinergic drugs can aggravate the gastrointestinal irritation of oral potassium salts, especially potassium chloride. 3. Non-steroidal anti-inflammatory analgesics aggravate the gastrointestinal reactions of oral potassium salts. 4. When used in combination with stored blood (30mmol/L of potassium for less than 10 days of storage, 65mmol/L of potassium for more than 10 days of storage), potassium-containing drugs and potassium-sparing diuretics, the chance of hyperkalemia increases, especially in patients with renal damage. 5. Angiotensin-converting enzyme inhibitors and cyclosporine A can inhibit aldosterone secretion and reduce urinary potassium excretion, so hyperkalemia is prone to occur when used in combination. 6. Heparin can inhibit the synthesis of aldosterone and reduce urinary potassium excretion, so hyperkalemia is prone to occur when used in combination. In addition, heparin can increase the chance of gastrointestinal bleeding.

Keep tightly closed.

1.0g

24 months

Hainan Lingkang Pharmaceutical Co., Ltd.

• Founded in:

  2013-04-22

• Address:

  No. 16, Yaogu Erheng Road, Yaogu Industrial Park, Haikou National High-tech Industrial Development Zone, Hainan Province

• Tax NO.:

  91460000062331438Q

• Registered Funds:

  200 million yuan

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