Chenodeoxycholic acid
Function and Efficacy
(1) Contraceptive pills can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. (2) Cholestyramine (cholestyramine), colestipol (colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption. They should not be used together.
Ingredients
Chenodeoxycholic acid. Its chemical name is: 3a,7a-dihydroxy-5b-cholanoic acid.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Chenodeoxycholic acidIngredients |
Contraceptive pills can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. Cholestyramine (Cholestyramine), colestipol (Colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption, so they should not be used together. More |
474-25-9 | 10 |
Appearance
It is white or light yellow crystalline powder with a peculiar odor.
Indication
The main function of chenodeoxycholic acid (CDCA) is to reduce the saturation of cholesterol in bile. After taking CDCA for most patients (when CDCA accounts for 70% of bile salts in bile), lipids return to the micelle state and cholesterol is in an unsaturated state, thereby dissolving and falling off the cholesterol in the stones. Large doses of CDCA (10-15 mg/kg per day) can inhibit the synthesis of cholesterol and increase the secretion of bile in patients with cholelithiasis, but the secretion of bile salts and phospholipids remains unchanged. At higher doses, the incidence of diarrhea is high and it has a certain toxicity to the liver.
Usage and Dosage
Oral administration, adjusted according to the condition, generally 12-15 mg/kg per day based on body weight, obese patients should increase the dosage slightly, up to 18-20 mg/kg per day. Take twice a day, morning and evening, with meals or milk. The course of treatment is more than 6 months.
Adverse Reactions
(1) The most common side effect is diarrhea (30% to 50%), which is characterized by cramps in the lower abdomen followed by watery stools. It is dose-related and disappears after the dose is reduced. Most patients can tolerate it if the dose is gradually increased. (2) A small number of patients (30%) may have a transient, reversible increase in AST (SGOT). (3) Some patients may experience skin itching, dizziness, nausea, and abdominal distension.
Precautions
It is contraindicated in patients with complete biliary obstruction and severe liver dysfunction.
Special Population Medication
Precautions for children: Not suitable for children under 6 years old. Oral administration: 10~15mg/kg, generally for more than 6 months. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited from using this product. Precautions for the elderly: Elderly patients, especially those over 60 years old, should use this product with caution.
Drug Interactions
(1) Contraceptive pills can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. (2) Cholestyramine (cholestyramine), colestipol (colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption. They should not be used together.
Storage
Keep in a dark, airtight, dry and cool place
Validity Period
24 months.
Manufacturer
Panjin Hengchanglong Pharmaceutical Co., Ltd.
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Founded in:
2002-01-09 -
Address:
Ping'an Township, Dawa County -
Tax NO.:
91211100734207588A -
Registered Funds:
60 million yuan -
Website:
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Email: