Chenodeoxycholic acid capsules

The main function of chenodeoxycholic acid (CDCA) is to reduce the saturation of cholesterol in bile. After taking CDCA for most patients (when CDCA accounts for 70% of bile salts in bile), lipids return to the micelle state and cholesterol is in an unsaturated state, thereby dissolving and falling off the cholesterol in the stones. Large doses of CDCA (10-15 mg/kg per day) can inhibit the synthesis of cholesterol and increase the secretion of bile in patients with cholelithiasis, but the secretion of bile salts and phospholipids remains unchanged. When the dose is large, the incidence of diarrhea is high and it is toxic to the liver.

Main ingredients and their chemical names: Chenodeoxycholic acid, chemical name 3α, 7α-dihydroxy-5β-cholanic acid

It is white or light yellow crystalline powder with a peculiar odor.

It is used for cholesterol cholelithiasis and also has certain efficacy on bile pigment stones and mixed stones.

Oral administration, adjust according to the condition, generally 12-15 mg/kg per day based on body weight, twice a day, with meals or milk; obese patients should increase the dosage slightly, up to 18-20 mg/kg per day, and the course of treatment is 6-24 months.

1The most common side effect is diarrhea (30% to 50%), which is characterized by cramps in the lower abdomen followed by watery stools. It is dose-related and disappears after the dose is reduced. Most patients can tolerate it if the dose is gradually increased. 2A small number of patients (30%) may have a transient, reversible increase in AST (SGOT). 3Some patients may experience skin itching, dizziness, nausea, and abdominal distension.

Pregnant women, patients with enteritis or liver disease should not use it.

Precautions for children: No references, not clear yet. Precautions for pregnancy and lactation: Prevented to use by pregnant women Precautions for the elderly: No references, not clear yet.

1. Contraceptive pills can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. 2. Cholestyramine (Cholestyramine), colestipol (Colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption. They should not be used together.

Keep away from light, tightly closed, and stored in a dry and cool place.

0.25g

60 months

Panjin Hengchanglong Pharmaceutical Co., Ltd.

• Founded in:

  2002-01-09

• Address:

  Ping'an Township, Dawa County

• Tax NO.:

  91211100734207588A

• Registered Funds:

  60 million yuan

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