Acyclovir Tablets

Antiviral drug. It has an inhibitory effect on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. After entering the cells infected by herpes virus, this product competes with deoxynucleoside for viral thymidine kinase or cell kinase, and the drug is phosphorylated into activated acyclovir triphosphate, and then inhibits viral replication in two ways: ① Interfering with viral DNA polymerase to inhibit viral replication; ② Under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. There are reports of carcinogenicity in in vitro cell transformation assays, but no evidence of carcinogenicity has been found in animal experiments. Some animal experiments show that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes. The carcinogenic and mutagenic effects of this product are still unclear. High-dose injection can cause testicular atrophy and reduced sperm count in animals. The drug can pass through the placenta, and animal experiments have confirmed that it has no effect on the embryo.

The main ingredient of this product is acyclovir, whose chemical name is 9-(2-hydroxyethoxymethyl)guanine.

This product is a white film-coated tablet, which appears white after removing the film coating.

For the treatment of herpes zoster and primary genital herpes.

Oral. 1. Common dosage (1) Acute herpes zoster: Adults take 0.2-0.8g each time, 5 times a day, for 7-10 days. (2) Genital herpes: ① Initial genital herpes: Adults take 0.2g each time, 5 times a day, for 10 days. ② Chronic recurrent genital herpes: Adults take 0.2-0.4g each time, 2 times a day, continue treatment for 4-6 months or 12 months, and re-evaluate. Based on the re-evaluation results, choose a treatment plan of 0.2g each time, 3 times a day or 0.2g each time, 5 times a day. The frequency and severity of untreated genital herpes may change over time. After 1 year of treatment, the frequency and severity of genital herpes infections should be re-evaluated to determine whether to continue treatment with this product. ③ Intermittent treatment: Timely treatment should be given at the early stage of recurrent symptoms. Adults take 200mg each time, once every 4 hours, 5 times a day, for more than 5 days. (3) Varicella: Children over 2 years old take 20 mg/kg orally, 4 times a day for 5 consecutive days. Adults and children weighing more than 40 kg: 0.8 g once, 4 times a day for 5 consecutive days. 2. Dosage adjustment: (1) Patients with acute and chronic renal failure: ① Common dose: 0.2 g once every 4 hours. When the creatinine clearance is 10 ml/min/1.73 m2, 0.2 g once 5 times a day. When the creatinine clearance is 0-10 ml/min/1.73 m2, 0.2 g once 2 times a day. ② Common dose: 0.4 g once every 12 hours. When the creatinine clearance is 10 ml/min/1.73 m2, 0.4 g once 2 times a day. When the creatinine clearance is 0-10 ml/min/1.73 m2, 0.2 g once 2 times a day. ③ The commonly used dose is 0.8g each time, once every 4 hours. When the creatinine clearance is 25ml/min/1.73m2, 0.8g each time, 5 times a day. When the creatinine clearance is 10-25ml/min/1.73m2, 0.8g each time, 3 times a day. When the creatinine clearance is 0-10ml/min/1.73m2, 0.8g each time, 2 times a day. (2) Hemodialysis: For patients who need hemodialysis, the half-life of acyclovir in plasma during hemodialysis is about 5 hours. 6 hours of hemodialysis will reduce the blood drug concentration by 60%. Therefore, the patient's dosage should be adjusted after each dialysis. (3) Peritoneal dialysis: There is no need to adjust the dose during administration.

Occasionally, dizziness, headache, joint pain, nausea, vomiting, diarrhea, stomach discomfort, loss of appetite, thirst, leukocytopenia, slight increase in proteinuria and urea nitrogen, skin itching, etc. may occur. Acne, insomnia, and menstrual disorders may occur occasionally with long-term administration.

It is contraindicated for those who are allergic to this product.

Precautions for children: The dosage for children under 2 years old has not been determined. Precautions for pregnancy and lactation: The drug can pass through the placenta. Although animal experiments have confirmed that it has no effect on the embryo, pregnant women still need to weigh the pros and cons of using the drug. The concentration of the drug in breast milk is 0.6 to 4.1 times the blood concentration. Although no abnormalities have been found in infants, breastfeeding women should use it with caution. Precautions for the elderly: Due to the decline of physiological renal function, the dosage and medication interval of this product need to be adjusted.

1. Combination with zidovudine can cause nephrotoxicity, manifested as deep lethargy and fatigue. 2. Competitive inhibition of organic acid secretion with probenecid. Combination with probenecid can slow down the excretion of this product, prolong the half-life, and accumulate the drug in the body.

Keep tightly closed in a cool, dry place.

0.1 g

36 months

Sichuan Kelun Pharmaceutical Co., Ltd.

• Founded in:

  2002-05-29

• Address:

  South 2nd Road, Xindu Satellite City Industrial Development Zone, Chengdu

• Tax NO.:

  9151010020260067X4

• Registered Funds:

  1,601,497,373 yuan

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