On ECHEMI
Home > Drugs > Podophyllotoxin ointment

Podophyllotoxin ointment

Function and Efficacy

This product is a plant extract and a cell division inhibitor in the metaphase of cell division. In vitro and in vivo tests have shown that this product has anti-tumor activity, can inhibit microtubule polymerization, inhibit nuclear mitosis, and stop it in the metaphase. This product is not easily absorbed orally and has serious toxic and side effects, so its systemic application is limited. In vitro efficacy tests for topical treatment of condyloma acuminatum have shown that this product can inhibit the incorporation of deoxynucleoside and DNA synthesis in cultured normal human skin keratinocytes and cervical cancer epithelial cells, hindering their division and proliferation. After external application of this product, it can inhibit the division and proliferation of epithelial cells with warty proliferation caused by human papillomavirus (HPV) infection, causing necrosis and shedding, thereby playing a role in treating condyloma acuminatum.

Ingredients

The main ingredient is podophyllotoxin, with the chemical name: [5R-(5α,5αβ,8aα,9α)],5,8,8α,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furan (3',4':6,7)naphtho-[2,3-d]-1,3-dioxetane-6-(5αH)-one

Name Description Content CAS NO. Manufacturer
PodophyllotoxinIngredients

This product is a plant extract and a cell division inhibitor in the metaphase of cell division. In vitro and in vivo tests have proven that this product has anti-tumor activity, can inhibit microtubule polymerization, inhibit nuclear mitosis, and stop it in the metaphase. When used externally to treat condyloma acuminatum, it can inhibit the division and proliferation of epithelial cells in warty proliferation caused by human papillomavirus (HPV) infection, causing necrosis and shedding, thereby playing a therapeutic role.

More
518-28-5 7

Appearance

This product is a white paste.

Indication

This product is used to treat condyloma acuminatum on the external genitalia and around the anus of men and women.

Usage and Dosage

Before applying the medicine, clean the affected area with a disinfectant and astringent solution (such as potassium permanganate solution, etc.) and wipe it dry; use a special medicine swab to apply the liquid medicine to the wart, apply it all over the wart, no need to repeat and try to avoid the liquid medicine from contacting normal skin and mucous membranes; the total amount of medicine should not exceed 1 ml, and after applying the medicine, expose the affected area to let the liquid medicine dry; use the medicine twice a day, once in the morning and once in the evening, for 3 consecutive days, and do not apply the liquid medicine for the next 4 days. This is a course of treatment. If there are still residual lesions, you can repeat a course of treatment, but no more than three courses of treatment. If there are still condyloma after three courses of treatment, the patient should seek medical attention for further examination.

Adverse Reactions

Not yet clear.

Precautions

It is contraindicated for people who are allergic to this drug, pregnant women, lactating women, and those with unhealed wounds after surgery.

Special Population Medication

Precautions for children: There is currently a lack of experimental data on the use of drugs in children, and it is recommended that children should not use the drug. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: It is not clear yet.

Drug Interactions

Not yet clear.

Storage

Keep in a dark place, tightly sealed and store below 30℃.

Packaging Specification

5g: 25mg/vial

Validity Period

36 months

Manufacturer

FU ZHOU HUA REN TANG MEDICINE Co., Ltd.

  • Founded in:

    1988-05-11
  • Address:

    Fuxing Investment Zone, Fuzhou
  • Tax NO.:

    91350100611306148K
  • Registered Funds:

    3.5 million yuan
  • Email:

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.