Indomethacin sustained-release tablets

This product has anti-inflammatory, antipyretic and analgesic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase. It stops the formation of pain nerve impulses in inflammatory tissues and inhibits inflammatory reactions, including inhibiting the chemotaxis of leukocytes and the release of lysosomal enzymes. As for the antipyretic effect, it acts on the hypothalamic temperature regulation center, causing peripheral vasodilation and sweating, which increases heat dissipation. This central antipyretic effect may also be related to the inhibition of prostaglandin synthesis in the hypothalamus.

The main ingredient of this product is indomethacin. Its chemical name is 2-methyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid. Molecular formula: C19H16ClNO4 Molecular weight: 357.79

This product is a green shaped film-coated tablet.

It is suitable for relieving symptoms during acute attacks of rheumatoid arthritis, rheumatic arthritis, ankylosing spondylitis, osteoarthritis and gout.

Oral administration. 75 mg once a day; or 75 mg twice a day; or as directed by a doctor. Rheumatoid patients should take 50-75 mg once a day at the beginning, and gradually increase to 25-50 mg after one week to achieve satisfactory results. The maximum daily dose should not exceed 200 mg. For acute conditions, such as gouty arthritis, take 100 mg once a day at the beginning, and then 75 mg twice a day to control pain, then quickly reduce the dose and stop taking the medicine.

This product has many adverse reactions. ① Gastrointestinal tract: 12.5% to 14% of patients experience indigestion, diarrhea, stomach pain, burning sensation in the stomach, nausea and acid reflux. Ulcers, gastric bleeding and gastric perforation occur in 2% to 5% of patients; ② Nervous system: headache, dizziness, vertigo, anxiety and insomnia occur in about 10% to 25%, and severe cases may have mental and behavioral disorders or convulsions; ③ Kidney: hematuria, edema, renal insufficiency occur, which are more common in the elderly; ④ Various types of rashes, the most serious of which is bullous erythema multiforme (Steven-Johnson syndrome); ⑤ The hematopoietic system is suppressed, resulting in aplastic anemia, leukopenia or thrombocytopenia, etc.; ⑥ Allergic reactions, asthma, angioedema and shock, etc.

It is contraindicated in patients with renal insufficiency, active gastric and duodenal ulcers.

Precautions for children: Not for use in children under 14 years old. Precautions for pregnancy and lactation: Not for use in pregnant and lactating women. Precautions for the elderly: Use with caution in elderly patients.

1. Long-term use of this product with acetaminophen may increase kidney toxicity. When used in combination with other non-steroidal anti-inflammatory drugs, the incidence of gastrointestinal ulcers increases. 2. Simultaneous use with aspirin or other salicylates does not increase the efficacy, but significantly increases gastrointestinal side effects and may increase bleeding tendency. 3. Drinking alcohol or using it with corticosteroids or adrenocorticotropic hormone may increase gastrointestinal ulcers or bleeding tendency. 4. When used in combination with heparin, oral anticoagulants, and thrombolytic drugs, there is a potential risk of increased bleeding tendency. 5. When used in combination with triamterene, it may cause gastric dysfunction. 6. When used in combination with colchicine and sulfinpyrazone, it may increase the risk of gastrointestinal ulcers and bleeding.

Keep away from light and store in sealed container.

25mg*10s

36 months

Mundipharma Company

• Founded in:

  1993-09-10

• Address:

  Building 20, No. 13, Jingsheng South Fourth Street, Jinqiao Science and Technology Industrial Base, Tongzhou Park, Zhongguancun Science and Technology Park, Tongzhou District, Beijing

• Tax NO.:

  91110000600024559C

• Registered Funds:

  837.7 million yuan

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