Carboplatin for injection

This product is a cyclic non-specific anticancer drug that acts directly on DNA, mainly cross-linking between and within the chains of cell DNA, destroying DNA and inhibiting tumor growth.

Main ingredient: Carboplatin Chemical name: cis-1,1-cyclobutanedicarboxylic acid diamine platinum Molecular formula: C6H12N2O4Pt Molecular weight: 371.26

This product is white or off-white freeze-dried loose mass or powder.

It is mainly used for ovarian cancer, small cell lung cancer, non-small cell lung cancer, head and neck squamous cell carcinoma, esophageal cancer, seminoma, bladder cancer, mesothelioma, etc.

Dissolve this product in 5% glucose injection to a concentration of 10mg/ml, then add 250-500ml of 5% glucose injection for intravenous drip. The general adult dosage is 200-400mg/m2 per body surface area, once every 3-4 weeks; 2-4 times as a course of treatment. It can also be used at a dose of 50mg/m2 per body surface area, once a day, for 5 consecutive days, repeated at intervals of 4 weeks.

1. Common reactions: ① Bone marrow suppression is the dose-limiting toxicity. White blood cells and platelets reach their lowest point 21 days after medication, and usually recover around 30 days after medication; the lowest point of granulocytes occurs 21 to 28 days after medication, and usually recovers around 35 days; white blood cell and platelet reduction is dose-related and has an accumulation effect; ② pain at the injection site. 2. Less common reactions: ① Allergic reactions (rash or itching, occasionally wheezing and coughing), which occur within a few minutes after medication; ② Peripheral neurotoxicity: numbness or tingling in the fingers or toes; ③ Ototoxicity: high-frequency hearing loss occurs first, and tinnitus is occasionally seen; ④ Blurred vision, mucositis or stomatitis; ⑤ Nausea and vomiting, constipation or diarrhea, loss of appetite, hair loss and dizziness, and occasionally allergic reactions and abnormal liver function.

1. Patients with obvious bone marrow suppression and liver and kidney dysfunction; 2. Patients allergic to cisplatin or other platinum-containing compounds; 3. Patients allergic to mannitol.

Precautions for children: There is not enough information to describe the standard method of using the drug in children. Precautions for pregnancy and lactation: The safety of carboplatin during pregnancy is not known. Carboplatin has been shown to have embryotoxicity and potential mutagenicity in many experiments. It is not known whether carboplatin is excreted in human milk. Precautions for the elderly: Use with caution in elderly patients.

1. Avoid using it with drugs that may damage kidney function, such as aminoglycoside antibiotics. 2. When used in combination with other anticancer drugs, the dose should be appropriately reduced. 3. This product should avoid contact with aluminum compounds and should not be mixed with other drugs for drip infusion.

Keep in a light-proof and airtight container.

0.1g

24 months

Qilu Pharmaceutical Co., Ltd.

• Founded in:

  1992-08-21

• Address:

  No. 317, Xinluo Street, High-tech Zone, Jinan City, Shandong Province

• Tax NO.:

  91370000614073351Q

• Registered Funds:

  600 million yuan

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