Granisetron Hydrochloride Capsules

This product is a highly selective 5-HT3 receptor antagonist, which has a good preventive and therapeutic effect on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Factors such as radiotherapy, chemotherapy and surgery can cause enterochromaffin cells to release 5-HT, which can activate the 5-HT3 receptors of the central nervous system or vagus nerve and cause vomiting reflex. The mechanism of this product to control nausea and vomiting is to antagonize the 5-HT3 receptors of the central chemoreceptor area and peripheral vagus nerve endings to inhibit the occurrence of nausea and vomiting. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation.

The main ingredient of this product is granisetron hydrochloride, whose chemical name is 1-methyl-N-(endo-9-azabicyclo[3,3,1]nonan-3-yl)-1H-indazole-3-carboxamide hydrochloride.

This product is a hard capsule, and the contents are white or off-white powder.

Used for nausea and vomiting caused by radiotherapy and cytotoxic chemotherapy.

Oral administration: The usual dosage for adults is 1 mg (1 tablet), twice a day, the first dose is taken 1 hour before chemotherapy, and the second dose is taken 12 hours after the first dose, or as directed by a doctor. No dosage adjustment is required for the elderly and those with impaired liver or kidney function.

Common adverse reactions include headache, fatigue, fever, constipation, and occasional transient asymptomatic increase in liver aminotransferase. These reactions are mild and do not require special treatment.

1. Patients who are allergic to this product or related compounds are prohibited from using this product. 2. Patients with gastrointestinal obstruction are prohibited from using this product.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

When used simultaneously with rifampicin or other liver enzyme inducing drugs, the blood concentration of this product will be reduced and the dosage should be appropriately increased.

Keep in a dry place, sealed and protected from light. The validity period is tentatively two years.

1mg

24 months

Chengdu Huashen Technology Group Co., Ltd. Pharmaceutical Factory

• Founded in:

  2001-09-17

• Address:

  No. 3, Section 2, Jinhua Road, Southwest Airlines Economic Development Zone, Chengdu

• Tax NO.:

  915101227323530630

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