Nicardipine Hydrochloride Sustained Release Capsules

This product is a calcium ion antagonist. It exerts a vasodilating effect by inhibiting the influx of calcium ions into vascular smooth muscle cells, thereby lowering blood pressure. This product has a high degree of vascular selectivity, and its calcium ion antagonist effect on vascular smooth muscle is 30,000 times stronger than its effect on myocardium. At the same time, it has shown a sodium excretion and diuretic effect in dog and rat experiments; it has also shown an effect of dilating the vertebral artery, coronary artery, femoral artery, and renal artery in anesthetized dogs; this product can increase the blood flow of major organs such as the brain, heart, and kidneys, and has a precise and lasting antihypertensive effect. Long-term use will not produce drug resistance, and it can inhibit the progression of myocardial hypertrophy caused by hypertension and prevent the occurrence of cerebral stroke.

The main ingredient of this product is: Nicardipine hydrochloride. Its chemical name is: 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid, 3-[beta;-(N-benzyl-N-methylamino)]ethyl ester-5-methyl ester hydrochloride. Molecular formula: C26H29N3O6HCl Molecular weight: 515.99

This product is a white transparent capsule, and the contents are yellow pill-like granules.

Essential hypertension. Also suitable for angina pectoris, sequelae of ischemic and hemorrhagic cerebrovascular accidents, etc.

Normally, for adults: take orally, twice a day, one tablet (40 mg) each time.

1. Common symptoms include edema of the ankles, dizziness, headache, and facial flushing. 2. Sometimes GOT, GPT, and γ-GTP increase, and occasionally bilirubin increases. 3. Less common symptoms include palpitations, fatigue, and tachycardia. 4. Sometimes constipation, abdominal pain, and occasionally loss of appetite, diarrhea, nausea, and vomiting occur. 5. Others: Occasionally, LDH, cholesterol, urea nitrogen, and creatinine increase, and occasionally granulocytopenia occurs.

1. Patients with allergic reaction to this product. 2. Patients with intracranial hemorrhage that has not yet completely stopped. 3. Patients with increased intracranial pressure in the acute stage of cerebral stroke. 4. Patients with severe aortic valve stenosis.

Precautions for children: The safety for premature infants, newborns, infants, toddlers, and children has not yet been established. Precautions for pregnancy and lactation: Pregnant women should use this product with caution. This drug can be excreted into breast milk, so it is best not to use it for breastfeeding women. Precautions for the elderly: The elderly should start with a low dose.

1 This product is well tolerated when used with beta-blockers. 2 This product increases blood concentration when used with cimetidine. 3 When this agent is used in combination with other antihypertensive drugs, additive effects may occur, so more attention should be paid when using it. 4 When this agent is used in combination with digoxin, measure the blood concentration of digoxin. 5 When this product is used in combination with cyclosporine, the blood concentration of cyclosporine increases. 6 In vitro, therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine, etc. added to human plasma do not change the protein binding rate of this product.

Keep in a light-proof and airtight container.

40mg

36 months