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Nicardipine hydrochloride

Nicardipine hydrochloride structure

CAS No:
54527-84-3
Formula:
C26H29N3O6.ClH
Chemical Name:
Nicardipine hydrochloride
Synonyms:
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester,hydrochloride (1:1);3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,methyl 2-[methyl(phenylmethyl)amino]ethyl ester,monohydrochloride;2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride;YC 93;Nicardipine hydrochloride;Perdipine;Cardene;Cardene (pharmaceutical);Vasonase;Ridene;Vasodin;Nicardal;Nicapress;Lescodil;RS 69216;Rycarden;Nerdipina;Lecibral;Nicant;RS 69216XX07-0;Bionicard;Dacarel;Barizin;Nicodel;Perdipina;Ranvil;Loxen;Nimicor;Rydene;Nicarpin;Cardepine;Cardene SR;152046-25-8
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.

Nicardipine hydrochloride Basic Attributes

Molecular Weight：

515.99

Exact Mass：

515.182312

EC Number：

259-198-4

HScode：

2933399090

Characteristics

PSA：

114

XLogP3：

5.33180

Appearance：

yellow powder

Melting Point：

168-170 °C

Boiling Point：

603.4°C at 760 mmHg

Flash Point：

318.7ºC

Water Solubility：

DMSO: ~1 mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/24/25

safety instructions：

36/37/39-45

RTECS Number：

US7972100

Marks：

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301-H311-H331

Nicardipine hydrochloride Use and Manufacturing

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Drug Function and Efficacy

It inhibits the transmembrane calcium ion influx between the myocardium and vascular smooth muscle without changing the blood calcium concentration, selectively dilates the coronary vascular smooth muscle, reduces peripheral vascular resistance, reduces myocardial oxygen consumption and total peripheral resistance, and increases coronary collateral circulation and coronary blood flow.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Nicardipine Hydrochloride and Glucose Injection
Ingredients	The main ingredient is nicardipine hydrochloride. The auxiliary materials are glucose and water for injection.
Indication	1 This product is well tolerated when used in combination with beta-blockers. 2 This product increases blood concentrations when used in combination with cimetidine. 3 This product does not increase blood concentrations of digoxin when used in combination with digoxin, but digoxin blood concentrations must be measured. 4 When this product is used in combination with cyclosporine, cyclosporine blood concentrations increase. 5 In vitro, therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine, and naproxen added to human plasma do not change the protein binding rate of this product.
Specifications	100ml: Nicardipine hydrochloride 10mg and glucose 5.5g
Manufacturer	Jinzhou Jiutai Pharmaceutical Co., Ltd.

Nicardipine Hydrochloride and Glucose Injection
Ingredients	Nicardipine Hydrochloride
Indication	1 This product is well tolerated when used in combination with beta-blockers. 2 This product increases blood concentrations when used in combination with cimetidine. 3 This product does not increase blood concentrations of digoxin when used in combination with digoxin, but digoxin blood concentrations must be measured. 4 When this product is used in combination with cyclosporine, cyclosporine blood concentrations increase. 5 In vitro, therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine, and naproxen added to human plasma do not change the protein binding rate of this product.
Specifications	100ml: Nicardipine hydrochloride 10mg and glucose 5.5g
Manufacturer	Liaoning Hishen Liansheng Pharmaceutical Co., Ltd.

Nicardipine Hydrochloride Tablets
Ingredients	Nicardipine Hydrochloride
Indication	1. It is well tolerated when used in combination with adrenergic beta-receptor blockers. 2. The plasma concentration of this product can be increased when used in combination with cimetidine, so it should be monitored carefully. 3. The blood concentration of digoxin has not been increased when used in combination with digoxin, but the blood concentration of digoxin must be measured. 4. The blood concentration of cyclosporine increases when used in combination with cyclosporine, so the blood concentration of cyclosporine must be closely monitored and the dose of cyclosporine must be reduced accordingly. 5. The addition of therapeutic concentrations of furosemide, propranolol, dimethoprim, warfarin, quinidine, and naproxen to human plasma in vitro does not change the protein binding rate of this product.
Specifications	10mg
Manufacturer	Henan Taloph Pharmaceutical Stock Co., Ltd.

See More Related Drugs

Registered Holders

WOCKHARDT LTD

Brazil
Active
LUSOCHIMICA SPA

Brazil
Active
OLON S.P.A.

Italy
Active

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Nicardipine hydrochloride 99% powder

CAS No.: 54527-84-3

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Content: 99%

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Nicardipine hydrochloride CAS 54527-84-3

CAS No.: 54527-84-3

Grade: Pharmaceutical Grade

Content: 99%

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Guide of Nicardipine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Nicardipine hydrochloride

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