Miconazole nitrate vaginal suppository

It is a broad-spectrum antifungal drug. It can inhibit the growth of most fungi at a concentration of 4 mg/L. Blastomyces and Histoplasma are highly sensitive to it. Cryptococcus, Candida, Coccidioides, etc. are also sensitive to it. This product interferes with the activity of cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol, the main steroid in the fungal cell membrane, damaging the fungal cell membrane and changing its permeability, resulting in leakage of important intracellular substances. This product can also inhibit the biosynthesis of triglycerides and phospholipids in fungi, inhibit the activity of oxidases and peroxidases, cause the accumulation of intracellular hydrogen peroxide, and lead to cell submicrostructure degeneration and cell necrosis. For Candida albicans, it can inhibit the process of transformation from spores to invasive hyphae.

Each capsule of this product contains 0.4g of miconazole nitrate as the main ingredient, and liquid paraffin and vaseline as auxiliary materials. The capsule shell contains gelatin, glycerin, titanium dioxide, sodium p-hydroxyphenylacetate, and sodium p-hydroxyphenylpropionate.

This product is a milky white oval soft-shell suppository, and its contents are white ointment made of a fat-soluble matrix.

Topical treatment of candidal vulvovaginal infection and superinfection caused by gram-positive bacteria.

Vaginal administration: After washing, place the soft capsule deep into the vagina. Take 1 capsule once a night for 3 consecutive days as a course of treatment. Even if the symptoms disappear quickly, the course of treatment should be completed and continued during menstruation.

Allergic reactions are rare, but most are mild. Common adverse reactions are local irritation, itching, and burning sensation, especially at the beginning of treatment. Pelvic cramps, urticaria, and skin papules can also occur.

It is contraindicated for those who are allergic to imidazoles or the components of the capsule shell.

Precautions during pregnancy and lactation: Do not use during the first 3 months of pregnancy.

1. Since this product can damage latex products such as diaphragms and condoms, avoid contact between this product and such products. 2. If taken simultaneously with other drugs such as coumarin derivatives, oral blood-lowering drugs or phenytoin, the effects and exacerbations of these drugs may be increased. 3. Systemic administration of miconazole nitrate is known to inhibit CYP3A4/2C9. Given the limited systemic absorption of this product by vaginal administration, drug interactions are unlikely to occur clinically. However, patients taking oral anticoagulants (such as warfarin) should use miconazole nitrate with caution and monitor the anticoagulant effect. Patients taking warfarin may experience bleeding (gingiva, ears) and hematoma when using vaginal preparations containing miconazole at the same time. 4. If you are using other drugs, consult a physician or pharmacist before using this product.

Keep in a dark and airtight container in a cool and dry place below 30℃.

0.4 g

24 months.