Trospium Chloride Tablets

This product is a synthetic tropic acid derivative with four ammonium structures. It is a parasympathetic nerve blocker with similar effects to atropine. It mainly works by competitively binding with the endogenous neurotransmitter acetylcholine to the postsynaptic membrane M-receptor. It reduces the tension of the parasympathetic nerves and removes the smooth muscle spasms caused by the parasympathetic nerves in the organs controlled by the parasympathetic nerves. It also has a certain effect on the gastrointestinal tract, bile duct and urinary tract. This product has low lipid solubility and is not easy to pass through the blood-brain barrier, and will not produce side effects of the central nervous system. Acute and chronic toxicity experiments on two rodents showed that the observable side effects were caused by the increase in pharmacodynamic activity, rather than specific target organ toxicity, and there was no difference between sexes. There was no reproductive toxicity at the maximum tolerated dose, and in vivo and in vitro experiments showed no gene mutation and carcinogenic effects.

The main ingredient of this product and its chemical name are: 3-dibenzoylnortropane-8-spiro-1-pyrrolidine chloride.

Trospium chloride tablets are smooth yellow-brown coated tablets.

Overactive bladder; frequent urination, nocturia, bladder dysfunction not caused by hormonal or organic diseases (bladder irritation, urinary urgency).

Oral administration, 2 times a day, 1 tablet each time (equivalent to 40 mg per day), or as directed by a doctor. The recommended dose for patients with severe renal insufficiency (creatinine clearance of 10-30 ml/min/1.73 m2) is 1 tablet per day or every other day (i.e. 20 mg per day or every other day). It should be taken with water on an empty stomach before meals, and the whole tablet should be taken.

Adverse reactions to this drug are rare, including dry mouth and constipation.

1. It is contraindicated for patients who are allergic to this product and its ingredients. 2. It is contraindicated for patients with urinary retention, gastric retention and uncontrolled angle-closure glaucoma.

Precautions for children: Children under 12 years old are prohibited from using this drug. Please keep the drug out of reach of children. Precautions for pregnancy and lactation: Only take this product as prescribed by your doctor after your doctor has carefully evaluated the benefits and risks of the drug, because there is currently no effective data on the use of this product during pregnancy. Experimental animal studies have shown that this product has no embryotoxicity. Precautions for the elderly: Not yet clear.

1. Enhance the anticholinergic effect of drugs: such as amantadine, tricyclic antidepressants, quinidine antihistamines and verapamil; enhance the cardiotonic effect of β-sympathomimetic drugs; reduce the positive motility of drugs such as metoclopramide and cisapride. 2. Since trospchloramine can affect the motility and secretion of the gastrointestinal tract, it cannot be ruled out that trospchloramine will affect the absorption of other drugs taken at the same time. 3. Since it cannot be ruled out that guar gum (Guar), cholestyramine and other drugs inhibit the absorption of trospchloramine, it is not recommended to use these drugs with trospchloramine. 4. In vitro experiments show that trospchloramine can affect the metabolism of cytochrome enzymes P450 related to drug metabolism (P4501A2, 2A6, 2C9, 2C19, 2D19, 2D6, 2E1, 3A4) to other

Keep sealed.

20mg (calculated as C25H30NO3Cl)

24 months

Yangtze River Pharmaceutical (Group) Co., Ltd.

• Founded in:

  2001-03-27

• Address:

  No. 1, South Yangtze River Road, Taizhou

• Tax NO.:

  913212007286987632

• Registered Funds:

  133 million yuan

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