Isosorbide dinitrate spray

Pharmacology: The main pharmacological effect of isosorbide dinitrate (ISDN) is to relax vascular smooth muscle. ISDN is metabolized in the body to form isosorbide mononitrate (ISMN), which releases nitric oxide (NO). NO is the same as endothelial relaxing factor, activating guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, and having a stronger dilating effect on veins. Venous dilation causes blood to remain in the periphery, reducing the amount of blood returning to the heart, and reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arterial dilation reduces peripheral vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Coronary artery dilation increases coronary perfusion. The overall effect is to reduce myocardial oxygen consumption, increase oxygen supply, and relieve angina pectoris. Toxicology: No carcinogenicity or mutagenicity was observed in animal experiments.

Main ingredients: The main ingredients of this product are: Isosorbide dinitrate. Molecular formula: C6H8N2O8 Molecular weight: 236.14

The liquid of this product in the pressure-resistant container is a colorless clear liquid. When the valve is pressed, the liquid will spray out in the form of mist particles.

It is used to prevent and treat various types of coronary heart disease and angina pectoris, especially for moderate and severe angina pectoris. When there are factors that induce angina pectoris, such as mental stress, overwork, or the presence of premonitory symptoms, using this product in advance can prevent angina pectoris attacks.

When using, first open the cap of the medicine bottle, the spray valve is at the top, the medicine bottle is vertical, press the spray valve several times until the spray is even, then use it. However, if it has not been used for a long time, you need to press the valve again until the spray is even before use. When using, point the spray nozzle at the mouth and press 4 times to achieve an effective dose of 2.5mg.

In the early stage of medication, nitrate-induced vasodilatory headache may occur, as well as facial flushing, dizziness, orthostatic hypotension and reflex tachycardia. Occasionally, blood pressure may be significantly reduced, bradycardia and angina pectoris may be aggravated, and collapse and syncope may rarely occur.

Acute circulatory failure (shock, circulatory collapse); severe hypotension (systolic blood pressure 90 mmHg = 90 mmHg); acute myocardial infarction with low filling pressure (unless under continuous hemodynamic monitoring); hypertrophic obstructive cardiomyopathy; constrictive pericarditis or cardiac tamponade; severe anemia; glaucoma; increased intracranial pressure; primary pulmonary hypertension; allergy to nitro compounds.

Not yet clear.

Keep away from light and store in airtight container.

10ml: 0.125g, each spray contains 0.625mg of isosorbide dinitrate, 200 sprays per bottle

Shanxi Shanyi Pharmaceutical Co., Ltd.

• Founded in:

  1985-05-16

• Address:

  No. 65, Gangyuan North Road, Taiyuan Zhongbei High-tech Industrial Development Zone

• Tax NO.:

  91140100110080099G

• Registered Funds:

  50 million yuan

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