Sorbitol (for oral use)
Function and Efficacy
Sorbitol monosaccharide is an isomer of mannitol. Its effect is similar to that of mannitol but weaker. After intravenous injection of a concentrated solution (25%) of this product, except for a small part converted into sugar, most of it is excreted in its original form through the kidneys. Due to the formation of blood hyperosmosis, it can dehydrate the surrounding tissues and brain parenchyma and be excreted from the urine along with the drug, thereby reducing intracranial pressure and eliminating edema. High efficacy appears 2 hours after injection, and the brain edema is gradually calmed, the tension disappears, and the cerebrospinal fluid pressure decreases. It is not metabolized in the body and is rarely reabsorbed in the renal tubules after glomerular filtration, playing an osmotic diuretic role. (1) Tissue dehydration effect. It increases the plasma colloidal osmotic pressure, causing water in the tissues (including the eyes, brain, cerebrospinal fluid, etc.) to enter the blood vessels, thereby reducing tissue edema, reducing intraocular pressure, intracranial pressure, and cerebrospinal fluid volume and pressure. (2) Diuretic effect. The diuretic mechanism is divided into two aspects. ① Increase blood volume and promote the secretion of prostaglandin I2, thereby dilating renal blood vessels and increasing renal blood flow, including renal medullary blood flow. The glomerular afferent arteriole dilates, the glomerular capillary pressure increases, and the cortical glomerular filtration rate increases. ② After glomerular filtration, very little (10%) of this drug is reabsorbed by the renal tubules, so it can increase the osmotic concentration of renal tubular fluid and reduce the reabsorption of water and Na+, Cl-, K+, Ca2+, Mg2+ and other solutes by the renal tubules. In the past, it was believed that this drug mainly acts on the proximal tubules, but animal puncture experiments found that after the application of large doses of sorbitol, the water and Na+ passing through the proximal tubules only increased by 10~20% and 4~5%, respectively; while the water and Na+ reaching the distal tubules increased by 40% and 25%, respectively. This suggests that the reduction in the reabsorption of water and Na in the loop of Henle plays an important role in the diuretic effect of sorbitol. This may be due to increased renal medullary blood flow, increased loss of urea and Na in the medulla, which destroys the medullary osmotic pressure gradient. Since the renal tubular fluid flow increases after sorbitol infusion, when certain drugs and poisons are poisoned, the concentration of these substances in the renal tubules decreases, the toxicity to the kidney is reduced, and the excretion through the kidney is accelerated.
Ingredients
Sorbitol
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| SorbitolIngredients |
Sorbitol monosaccharide is an isomer of mannitol, and its effect is similar to that of mannitol but weaker. After intravenous injection of a concentrated solution (25%), except for a small part converted into sugar, most of it is excreted in its original form through the kidneys, forming blood hyperosmosis, which can dehydrate the surrounding tissues and brain parenchyma and be excreted from the urine along with the drug, thereby reducing intracranial pressure and eliminating edema. High efficacy appears 2 hours after injection, and the brain edema gradually subsides, the tension disappears, the cerebrospinal fluid pressure decreases, it is not metabolized in the body, and after glomerular filtration, it is rarely reabsorbed in the renal tubules, playing an osmotic diuretic role. (1) Tissue dehydration effect: Increases plasma colloidal osmotic pressure, causing water in tissues (including eyes, brain, cerebrospinal fluid, etc.) to enter the blood vessels, reducing tissue edema, reducing intraocular pressure, intracranial pressure, and cerebrospinal fluid volume and pressure. (2) Diuretic effect: ① Increase blood volume, promote the secretion of prostaglandin I2, dilate renal blood vessels, increase renal blood flow including renal medullary blood flow, dilate glomerular afferent arterioles, increase glomerular capillary pressure, and increase cortical glomerular filtration rate. ② After glomerular filtration, very little (10%) of this drug is reabsorbed by the renal tubules, increasing the osmotic concentration of the renal tubular fluid and reducing the reabsorption of water and Na+, Cl-, K+, Ca2+, Mg2+ and other solutes by the renal tubules. Since the renal tubular fluid flow increases after the infusion of sorbitol, when certain drugs and poisons are poisoned, the concentration of these substances in the renal tubules decreases, the toxicity to the kidneys is reduced, and the excretion through the kidneys is accelerated. More |
50-70-4 | 23 |
Appearance
This product is white crystalline powder, odorless, sweet and hygroscopic.
Indication
Cerebral edema and glaucoma, can also be used for edema and oliguria with normal heart and kidney function.
Usage and Dosage
Generally used for indigestion, 2-4g each time (1/3-2/3 bag), three times a day; for constipation, take once a night, 6g (1 bag) each time, with warm water before bedtime or as directed by a doctor.
Adverse Reactions
This product has minimal side effects and can be taken for a long time.
Precautions
Not yet clear.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Sealed, store in a cool and dry place.
Packaging Specification
6g
Validity Period
24 months
Manufacturer
Yichang Humanwell Pharmaceutical Co., Ltd.
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Founded in:
2001-08-08 -
Address:
No. 19, Dalian Road, Yichang Development Zone, Hubei Province -
Tax NO.:
91420500730843405M -
Registered Funds:
293,527,036 yuan -
Website:
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Email: