On ECHEMI
Home > Drugs > Isosorbide oral solution

Isosorbide oral solution

Function and Efficacy

This product is a dehydrated derivative of sorbitol. Its mechanism of action is similar to that of intravenously injected mannitol and sorbitol. It is an oral osmotic dehydration diuretic. It increases plasma osmotic pressure, causing water in tissues (including eyes, brain, cerebrospinal fluid, etc.) to enter blood vessels, thereby reducing tissue edema, intraocular pressure, intracranial pressure, and cerebrospinal fluid volume and pressure. The LD50 for mice and rats is 23.3g/kg and 25.8g/kg for oral administration, and 17.6g/kg and 21.02g/kg for intraperitoneal administration, respectively.

Ingredients

Main ingredients: 1,4:3,6-dianhydro-D-sorbitol.

Appearance

This product is a colorless or slightly yellow clear liquid.

Usage and Dosage

Oral administration, 40-50 ml at a time, 3 times a day; for children, 0.5 g/kg at a time, 3 times a day or as directed by a doctor.

Adverse Reactions

The main adverse reactions include nausea, diarrhea, loss of appetite, and occasional abdominal pain. Long-term use often causes electrolyte imbalance.

Precautions

Patients with active intracranial bleeding and intracranial hematoma will have bleeding aggravated by volume expansion.

Special Population Medication

Precautions for children: There are no special precautions for children to use this drug. Precautions for pregnancy and lactation: It is not clear whether it can be secreted through breast milk. Precautions for the elderly: The elderly are more likely to suffer from kidney damage after using this drug. With age, the chance of kidney damage increases, so the dosage should be appropriately controlled.

Drug Interactions

1. It can increase the toxicity of digitalis, which is related to hypokalemia; 2. It can increase the diuretic and intraocular pressure-lowering effects of diuretics and carbonic anhydride inhibitors, and the dose should be adjusted when combined with these drugs. Drug overdose: It can easily cause diarrhea, and blood pressure, electrolytes and renal function should be closely monitored.

Storage

Keep in a light-proof and airtight container. Valid for 2 years.

Packaging Specification

100ml:50g

Validity Period

24 months

Manufacturer

Jinan Yuteng Pharma. Co., Ltd.

  • Founded in:

    2000-06-23
  • Address:

    Sunguanzhuang Industrial Park, Yushan Street, Pingyin County, Jinan City, Shandong Province
  • Tax NO.:

    913701007238923802
  • Registered Funds:

    5 million yuan
  • Email:

Other Drugs of Jinan Yuteng Pharma. Co., Ltd.

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.