Theophylline Tablets

This product is the choline salt of theophylline, containing 60%~64% theophylline, and has similar effects to theophylline. It is easily absorbed orally, has little gastrointestinal irritation, can tolerate a larger dose, and has less effect on the heart and nervous system. This product has a direct relaxant effect on the smooth muscle of the respiratory tract. Its mechanism of action is relatively complex. In the past, it was believed that it was caused by inhibiting phosphodiesterase and increasing the intracellular cAMP content. Recent experiments have shown that the bronchodilator effect of theophylline is partly due to the release of endogenous adrenaline and noradrenaline. In addition, theophylline is a purine receptor blocker that can counteract the contractile effect of adenine and other substances on the respiratory tract. Theophylline can enhance the contraction force of the diaphragm, especially when the diaphragm contraction is weak, so it is beneficial to improve respiratory function.

The main ingredients of this product and its chemical name are: The main ingredient of this product is theophylline, and its chemical name is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione N,N,N-trimethyl-2-hydroxyethylammonium salt. Its structural formula is: Molecular formula: C12H21N5O3 Molecular weight: 283.33.

This product is white tablets.

Suitable for bronchial asthma and also for cardiac asthma.

1. The usual oral dose for adults is 0.1-0.2g (1-2 tablets) at a time, 3 times a day; the maximum dose is 0.5g (5 tablets) at a time, 1g a day. 2. The usual oral dose for children is 10-15mg/kg per day according to body weight, divided into 3-4 times.

The toxicity of theophylline often occurs when the serum concentration is 15-20mu;g/ml, especially at the beginning of treatment. Common symptoms in the early stage include nausea, vomiting, irritability, insomnia, etc. When the serum concentration exceeds 20mu;g/ml, tachycardia and arrhythmia may occur. When the theophylline content in the serum exceeds 40mu;g/ml, fever, dehydration, convulsions and other symptoms may occur, and severe cases may even lead to respiratory and cardiac arrest and death.

It is contraindicated for patients who are allergic to this product, those with active peptic ulcers and uncontrolled convulsions.

Precautions for children: The plasma clearance rate of newborns may be reduced and the serum concentration may increase, so it should be used with caution. Precautions for pregnancy and lactation: This product can pass through the placental barrier and can also be secreted into breast milk and excreted with breast milk. It should be used with caution by pregnant women, parturients and lactating women. Precautions for the elderly: The plasma clearance rate of the elderly is reduced and the potential toxicity is increased. It should be used with caution in patients over 55 years old.

1. Diltiazem and verapamil can interfere with the metabolism of theophylline in the liver. When used in combination with this product, the blood concentration and toxicity of this product will be increased. 2. Cimetidine can reduce the liver clearance rate of this product. When used in combination, it can increase the serum concentration and (or) toxicity of theophylline. 3. Certain antibacterial drugs, such as erythromycin, roxithromycin, and clarithromycin of the macrolide class; enoxacin, ciprofloxacin, ofloxacin, and levofloxacin of the fluoroquinolone class; clindamycin and lincomycin, etc. can reduce the clearance rate of theophylline and increase its blood concentration, especially erythromycin and enoxacin. When theophylline is used in combination with the above drugs, the dosage should be appropriately reduced. 4. Phenobarbital, phenytoin, and rifampicin can induce liver drug enzymes, accelerate the liver clearance rate of theophylline, and reduce the serum concentration of theophylline; theophylline also interferes with the absorption of phenytoin, and the plasma concentrations of both are reduced. When used in combination, the dosage should be adjusted and the blood concentration should be monitored. 5. 6. When used in combination with lithium salts, it can increase the renal excretion of lithium, affecting the effect of lithium salts. 6. When used in combination with mexiletine, it can reduce the clearance rate of theophylline and increase the concentration of theophylline in plasma, requiring dose adjustment. 7. When used in combination with caffeine or other xanthine drugs, it can increase their effects and toxicity.

Sealed, store in a dry place.

0.1g

36 months.

DHS Pharmaceutical Co., Ltd.

• Founded in:

  1996-08-27

• Address:

  No. 92, Longhua Road, Tiefeng District, Qiqihar City, Heilongjiang Province

• Tax NO.:

  91230200128540823D

• Registered Funds:

  5.272885 million yuan

• Email:

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