Pentoxifylline Enteric-coated Tablets

This product is a non-specific peripheral vasodilator. Its metabolites have the effects of improving blood viscosity and microcirculation. It can increase tissue oxygen carrying capacity, improve red blood cell deformability, and inhibit neutrophil adhesion and activation, playing a therapeutic role in ischemic stroke and peripheral vascular disease.

The main ingredient of this product is pentoxifylline, whose chemical name is 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione.

This product is an enteric-coated tablet, which appears white after removing the coating.

It is mainly used to improve cerebral circulation after ischemic stroke, and can also be used to treat peripheral vascular diseases such as chronic occlusive vasculitis with intermittent claudication.

Take orally 0.2-0.4g each time, 2-3 times a day.

1 Common adverse reactions include: dizziness, headache, anorexia, abdominal distension, vomiting, etc., with an incidence rate of more than 5%, and up to about 30%. 2 Less common adverse reactions include cardiovascular system: decreased blood pressure, irregular breathing, edema; nervous system: anxiety, depression, convulsions; digestive system: anorexia, constipation, dry mouth, thirst; skin angioedema, rash, shiny nails; blurred vision, conjunctivitis, enlarged central blind spot, as well as decreased taste, increased salivation, leukopenia, muscle soreness, swollen neck glands and weight changes. 3 Occasional adverse reactions include angina pectoris, arrhythmia; jaundice, hepatitis, abnormal liver function, decreased blood fibrinogen, aplastic anemia and leukemia, etc.

It is contraindicated for patients who are allergic to pentoxifylline or other methylxanthines. It is contraindicated for patients with acute myocardial infarction, severe coronary artery sclerosis, severe hypertension, cerebral hemorrhage and retinal hemorrhage.

Precautions for children: Not clear. Precautions for pregnancy and lactation: Contraindicated for pregnant women. This product and its metabolites can be secreted by breast milk, so it is best not to use it for lactating women. Precautions for the elderly: Test data show that the AUC of patients aged 60 to 68 years was significantly higher than that of the 22 to 30-year-old group, and the clearance time was prolonged. Please follow the doctor's advice when taking the medicine.

1. When used in combination with antiplatelet or anticoagulant drugs, the coagulation time is prolonged. The dose should be reduced when this drug is used in combination with patients taking warfarin. 2. When used in combination with theophylline drugs, there is a synergistic effect, which will increase the efficacy and toxicity of theophylline. Therefore, the doses of theophylline and oxoxifylline must be adjusted. 3. When used in combination with antihypertensive drugs, beta blockers, digitalis, diuretics, antidiabetic and antiarrhythmic drugs, there is no obvious cross-reaction, but it may slightly aggravate the drop in blood pressure, so attention should be paid.

Keep in a light-proof and airtight container.

0.1 g

24 months