Amoxicillin and Dicloxacillin Sodium Capsules

This product is a compound preparation composed of amoxicillin and dicloxacillin sodium. Amoxicillin is a broad-spectrum penicillin antibiotic, and dicloxacillin is isoxacillin, which is not easily destroyed by penicillinase. This product has antibacterial effects on the following bacteria in vitro. Gram-positive bacteria: Staphylococcus aureus, group A and group B hemolytic streptococci, viridans streptococci, fecal streptococci, pneumococci, etc. Gram-negative bacteria: Neisseria gonorrhoeae, meningococci, influenza and parainfluenza Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella bacteria, etc. Anaerobic bacteria: Clostridium, Actinomyces bacteria, etc.

This product is a compound preparation, and its components are: each tablet contains 0.25g of amoxicillin and 0.125g of dicloxacillin.

Gray/yellow size 0 capsules contain white or off-white granular powder.

This product is suitable for the following infections caused by sensitive bacteria including Staphylococcus aureus (β-lactamase-producing bacteria and non-β-lactamase-producing bacteria), Staphylococcus epidermidis (β-lactamase-producing bacteria and non-β-lactamase-producing bacteria), Streptococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Clostridium, Peptococcus, Haemophilus, Escherichia coli, Bacteroides and other Gram-positive bacteria and Gram-negative bacteria: 1. Upper respiratory tract infections: such as sinusitis, tonsillitis, otitis media, etc. 2. Lower respiratory tract infections: such as acute and chronic bronchitis, lobar and bronchial pneumonia, empyema, lung abscess, etc. 3. Skin and soft tissue infections: such as furuncle, abscess, cellulitis, wound infection, intra-abdominal sepsis, etc. 4. Genitourinary tract infections: such as cystitis, urethritis, pyelonephritis

Usage: Oral. Dosage: For adults and children weighing more than 40kg, the usual dosage is 2 capsules each time (containing 0.5g amoxicillin and 0.25g dicloxacillin), once every 6 hours. For severe infections and respiratory tract infections: 3 capsules each time (0.75g amoxicillin and 0.375g dicloxacillin).

Common adverse reactions of this product include diarrhea, loose stools, nausea, skin flushing, rash, vomiting, itching, etc. This product may also cause abdominal discomfort, bloating and headache.

It is contraindicated for patients who are allergic to penicillins.

Precautions for children: 1. Please consult a physician or pharmacist for dosage for children. 2. Children must use under adult supervision. Precautions for pregnancy and lactation: Animal reproductive studies have shown that this product can cross the placenta, but there is no sign of damage to the fetus. There is no data on the secretion of this product in breast milk. The safety of use in pregnant and lactating women has not been confirmed so far, so this product should only be used when pregnant or lactating women have no appropriate choice. Precautions for the elderly: The dosage or medication interval should be adjusted according to the renal function under the guidance of a physician.

1. Benzenesulfonic acid can reduce the secretion of amoxicillin and dicloxacillin sodium in the renal tubules. Co-use can prolong the half-life of amoxicillin and dicloxacillin sodium. 2. The combined use of allopurinol and ampicillin can significantly increase the occurrence of rash compared with the use of ampicillin alone. It is not known whether the increase in rash is caused by allopurinol or by excessive toxin components in the urine. There is no data to suggest that allopurinol and amoxicillin and dicloxacillin sodium can be used together. Amoxicillin and dicloxacillin sodium should not be used together with disulfiram.

Seal tightly and store in a cool, dark and dry place (not exceeding 20°C).

0.375 g (0.25 g of C16H19N3O5 flakes and 0.125 g of C19H17C2N3O5 flakes)

24 months.