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Methoxsalen Liniment

Function and Efficacy

This product (8-methoxypsoralen) is a photosensitizer extracted from the seeds of the plant Ammi serrata on the banks of the Nile River. It has a photodynamic effect, making the skin sensitive to sunlight or artificial ultraviolet rays. Its action spectrum is between 320 and 380nm, with the greatest effect at 365nm. -Toxicological properties: Animal tests show that methoxsalen has no teratogenic effect. Small-scale human clinical trial data also did not show teratogenic effects.

Ingredients

The main ingredient of this product is methoxsalen, and its chemical name is: 9-methoxy-7H-furan[3,2-g][1]benzopyran-7-one

Name Description Content CAS NO. Manufacturer
8-MethoxypsoralenIngredients

Photosensitizer, with photodynamic effects, makes the skin sensitive to sunlight or artificial ultraviolet light. Its action spectrum is between 320 and 380nm, with the greatest effect at 365nm. Animal tests have shown that methoxsalen has no teratogenic effect. Small-scale human clinical trial data also did not show teratogenic effects.

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298-81-7 10

Appearance

This product is a colorless clear solution.

Indication

This product is used for vitiligo and psoriasis.

Usage and Dosage

Dosage and Administration: For initial treatment, the drug needs to be diluted 4-5 times with 75% alcohol. As the skin's tolerance to the drug increases, it can be diluted 2-3 times before use. Apply the drug to the affected area with a cotton swab or brush, and be careful not to apply it to areas other than the affected area. After 1-2 hours, irradiate with sunlight or ultraviolet rays (320-380nm U.V.A.). The initial exposure time is 0.5-1 minute, and then increase by 1 minute every week. When obvious erythema reaction occurs, the exposure dose will not be increased. Treat every other day or once a day. The effect is better when used in combination with external use (for the method of internal use, please refer to the instructions for Minbering tablets). The course of treatment depends on the indication.

Adverse Reactions

1Excessive ultraviolet radiation for a long time may cause erythema, blisters, bullae, pain and desquamation at the application site, which can be restored after stopping the drug. 2Some patients may experience skin itching after treatment, which can be relieved by taking anti-allergic drugs. 3Some patients may develop hyperpigmentation at or around the skin after treatment, which can be restored after stopping the drug.

Precautions

1. Patients with lupus erythematosus, erythropoietic porphyria, xeroderma pigmentosum and other photosensitive diseases. 2. Patients with a history of skin cancer. 3. Patients who have used arsenic-containing drugs or radiotherapy. 4. Patients with aphakia (the risk of retinal damage is significantly increased due to the absence of a lens). 5. Patients with a history of specific reactions or allergies to psoralen. 6. Patients with melanoma or a history of melanoma.

Special Population Medication

Precautions for children: Not for use in children under 12 years old. Precautions for pregnancy and lactation: Not recommended for treatment during pregnancy. Precautions for the elderly: Not for use in the elderly and infirm.

Drug Interactions

Avoid concomitant use with drugs or foods that may have potential photosensitizing properties.

Storage

Keep in a sealed, dry place away from light.

Packaging Specification

0.0075

Validity Period

48 months

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