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8-Methoxypsoralen

8-Methoxypsoralen structure

CAS No:
298-81-7
Formula:
C12H8O4
Chemical Name:
8-Methoxypsoralen
Synonyms:
7H-Furo[3,2-g][1]benzopyran-7-one,9-methoxy-;5-Benzofuranacrylic acid,6-hydroxy-7-methoxy-,δ-lactone;9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one;8-MOP;Ammoidin;Meladinin;Meloxine;Methoxa-Dome;Methoxsalen;8-Methoxy[furano-3′,2′:6,7-coumarin];8-Methoxypsoralen;Oxsoralen;Xanthotoxin;8-Methoxypsoralene;Xanthotoxine;Meladoxen;Meladinine;Oxypsoralen;8-MP;New-Meladinin;Puvalen;8-Methoxy-6,7-furanocoumarin;Puvamet;Geroxalen;Uvadex;Oxsoralen-Ultra;Oxsoralen Lotion;Ammodin;NSC 45923;Deltapsoralen;Methoxsalene;Vitpso;5-Demethoxyisoimpinellin;12692-94-3
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.Target: CYP (cytochrome P-450)Methoxsalen is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive

8-Methoxypsoralen Basic Attributes

Molecular Weight：

216.19

Exact Mass：

216.19

BRN：

196453

EC Number：

206-066-9

HScode：

2932999099

Characteristics

PSA：

48.7

XLogP3：

1.9

Appearance：

white to yellow Needle-Like Crystals or Powder

Density：

1.539 g/cm³

Melting Point：

148 °C

Boiling Point：

414.8°C at 760 mmHg

Flash Point：

204.7±28.7 °C

Refractive Index：

1.635

Water Solubility：

Practically insoluble in water

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Vapor Pressure：

2.15X10-6 mm Hg at 25 deg C (est)

Toxicity：

LD50 i.p. in rats: 470 ±30 mg/kg (Hakim)

Explosive limit：

Combustible

Odor：

Odorless

Taste：

Bitter taste followed by tingling sensation

PH：

pH = 5.5

Safety Information

Packing level：

I; II; III

Hazard category：

6.1

Transport codes：

3216

wgk germany：

hazard class code：

22-43-46-45-34

safety instructions：

36/37-53-45-36/37/39-26

RTECS Number：

LV1400000

Marks：

Xn,T

Stability/Shelf Life：

Stable under recommended storage conditions.

Precautionary statement(s)：

P280-P301 + P312 + P330

Hazard Statements：

H302-H317

8-Methoxypsoralen Use and Manufacturing

A potent suicide inhibitor of cytochrome P-450.

Computed Properties

Molecular Weight:216.19
XLogP3:1.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:216.04225873
Monoisotopic Mass:216.04225873
Topological Polar Surface Area:48.7
Heavy Atom Count:16
Complexity:325
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Photosensitizer, with photodynamic effects, makes the skin sensitive to sunlight or artificial ultraviolet light. Its action spectrum is between 320 and 380nm, with the greatest effect at 365nm. Animal tests show no teratogenic effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Methoxsalen Tablets
Ingredients	The main ingredient of this product is methoxsalen, and its chemical name is: 9-methoxy-7H-furan[3,2-g][1]benzopyran-7-one
Indication	Avoid concomitant use with drugs or foods that may have potential photosensitizing properties.
Specifications	5mg
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Methoxsalen solution
Ingredients	The main ingredient of this product is methoxsalen, and its chemical name is: 9-methoxy-7H-furan[3,2-g][1]benzopyran-7-one
Indication	Do not take other photosensitizing drugs during treatment. The use of this product with phenothiazines can aggravate the photochemical damage to the choroid, retina and lens.
Specifications	0.5%
Manufacturer	Jiangsu Disainuo Pharmaceutical Co., Ltd.

Methoxsalen Liniment
Ingredients	The main ingredient of this product is methoxsalen, and its chemical name is: 9-methoxy-7H-furan[3,2-g][1]benzopyran-7-one
Indication	Avoid concomitant use with drugs or foods that may have potential photosensitizing properties.
Specifications	0.0075

See More Related Drugs

Registered Holders

SOLARA A PHARMA SCIENCES LTD

United States
Active
Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active
China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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