Artesunate for injection

Pharmacology: This product is a derivative of target=_blank artemisinin. It has a strong and rapid killing effect on the erythrocytic stage of malarial parasites and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is not very clear, but it mainly interferes with the function of mitochondria, the surface membrane of malarial parasites. Artemisinin changes the membrane structure of malarial parasites by affecting the ultrastructure of the erythrocytic stage. Due to the effect on the food vesicle membrane, the malarial parasites' nutrient intake is blocked. When the malarial parasites lose a large amount of cytoplasm and nutrients and cannot be supplemented, they die quickly. Its mode of action is through its internal peroxide (dioxygen) bridge, mediated by the free iron produced after the decomposition of target=_blank hemoglobin, to produce unstable organic free radicals and/or other electrophilic mediators, and then form covalent adducts with malarial parasite proteins, causing the malarial parasite to die. Toxicology: Animal toxicology experiments show that this product has certain embryotoxicity, which is manifested as embryo absorption.

Artesunate.

White crystalline powder, stable at room temperature for 2 to 3 years.

It is suitable for the rescue of cerebral malaria and various severe malaria.

Intravenous injection. Before use, add 0.6 ml of the attached 5% sodium bicarbonate injection, shake for 2 minutes, and after it is completely dissolved, add 5.4 ml of 5% glucose injection or glucose sodium chloride injection to dilute it so that each 1 ml of solution contains 10 mg of artesunate, and slowly inject it intravenously. 1 vial for the first time (or 1.2 mg/kg according to body weight), 1.5 mg/kg according to body weight for children under 7 years old. Repeat the injection once each 4, 24, and 48 hours after the first dose. For critically ill patients, the first dose can be increased to 120 mg, and a course of treatment is 3 days, with a total dose of 240-300 mg.

Not yet clear.

Pregnant women and those who are allergic to this product are prohibited from using it.

Not yet clear.

Sealed, stored in a cool, dark and dry place. Stable at room temperature for 2 to 3 years.

60mg

Guilin Pharmaceutical Co., Ltd.

• Founded in:

  2001-06-22

• Address:

  No. 43, Qilidian Road, Guilin

• Tax NO.:

  91450300729742527H

• Registered Funds:

  285.0303 million yuan

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