Compound acetylsalicylic acid tablets
Function and Efficacy
It is a compound antipyretic and analgesic drug. Aspirin and phenacetin both have antipyretic and analgesic effects, can inhibit the synthesis and release of prostaglandins in the hypothalamus, restore the normal responsiveness of the receptor neurons in the temperature regulation center, and play an antipyretic and analgesic role; aspirin also has analgesic, anti-inflammatory and anti-rheumatic effects by inhibiting the synthesis of peripheral prostaglandins, etc. Aspirin also has the effect of inhibiting platelet aggregation. Caffeine is a central nervous system stimulant that can excite the cerebral cortex, increase sensitivity to the outside world, and constrict cerebral blood vessels, enhancing the effect of the first two drugs in relieving headaches. Acute toxicity test results: The oral LD50 of rats is 1500mg/kg; the oral LD50 of mice is 1100mg/kg.
Ingredients
The main ingredients of this product and their chemical names are: This product is a compound preparation, and its components are: each tablet contains 220mg of aspirin, 150mg of phenacetin and 35mg of caffeine.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Acetylsalicylic acidIngredients |
It has antipyretic and analgesic effects, can inhibit the synthesis and release of prostaglandins in the hypothalamus, restore the normal responsiveness of the receptor neurons in the temperature regulation center, and play an antipyretic and analgesic role; it also has analgesic, anti-inflammatory and anti-rheumatic effects by inhibiting the synthesis of peripheral prostaglandins, etc., and also has the effect of inhibiting platelet aggregation More |
50-78-2 | 35 | |
| PhenacetinIngredients |
It has antipyretic and analgesic effects, can inhibit the synthesis and release of prostaglandins in the hypothalamus, restore the normal responsiveness of the receptor neurons in the temperature regulation center, and thus play an antipyretic and analgesic role. More |
62-44-2 | 7 |
Appearance
This product is white tablets.
Indication
Salicylic acid analgesics, anti-inflammatory, antipyretics, anti-rheumatic and platelet inhibition drugs can be used clinically in the following situations. (1) Analgesics and antipyretics: They can relieve mild or moderate pain, such as headaches, toothaches, neuralgia, muscle pain and menstrual pain. They are also used to reduce fever for colds, flu, etc. This product can only relieve symptoms and cannot treat the causes of pain and fever, so other drugs must be used at the same time for causal treatment. (2) Anti-inflammatory and anti-rheumatic: It is the first choice for the treatment of rheumatic fever. After taking the medicine, it can reduce fever, reduce inflammation, improve joint symptoms, and reduce erythrocyte sedimentation rate, but it cannot eliminate the basic pathological changes of rheumatism, nor can it prevent heart damage and other complications. If there is obvious myocarditis, it is generally recommended to use adrenal cortex hormones first, and then add this product after the rheumatic symptoms are controlled and before the hormone is stopped.
Usage and Dosage
Oral administration, Adults: 1-2 tablets at a time, 3 times a day after meals.
Adverse Reactions
This product is a compound tablet mainly composed of aspirin and phenacetin. The more common adverse reactions of aspirin include gastrointestinal reactions such as nausea, vomiting, upper abdominal discomfort or pain, which usually disappear after stopping the drug; gastrointestinal bleeding or ulcers may occur when used for a long time or in large quantities; reversible tinnitus and hearing loss may occur after taking a certain course of treatment; a few patients may develop allergic reactions such as asthma, urticaria, angioedema or shock, which may lead to death in severe cases; excessive doses may cause liver and kidney damage. Phenacetin can cause renal papillary necrosis, interstitial nephritis and acute renal failure, and may even induce renal pelvic cancer and bladder cancer. Phenacetin is also easy to use hemoglobin to form methemoglobin, which reduces the oxygen-carrying capacity of the blood and causes cyanotic reactions. In addition, phenacetin can also cause hemolysis and hemolytic anemia, and has certain toxicity to the retina. Long-term use of phenacetin can also cause drug dependence. Phenacetin can also cause liver damage.
Precautions
It is contraindicated for patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs and caffeine, hemophilia, active peptic ulcer and other gastrointestinal bleeding. It is contraindicated for infants under 3 months old.
Special Population Medication
Precautions for children: Children, especially those with fever and dehydration, are prone to toxic reactions; children with acute febrile diseases, especially influenza and chickenpox, may develop Reye syndrome if this product is used. Children under 6 years old should be used with caution, and infants under 3 months old are prohibited. Precautions for pregnancy and lactation: Aspirin in this product easily crosses the placenta. Considering the possible impact on the fetus, it is not suitable for pregnant women. After lactating women take this product, aspirin can reach a certain concentration in breast milk, so long-term high-dose use may cause adverse reactions such as bleeding tendency in infants. Precautions for the elderly: Elderly patients are prone to toxic reactions due to decreased renal function when taking this product, so it should be used with caution or in an appropriate reduced dose.
Drug Interactions
Not yet clear.
Storage
Sealed, store in a dry place.
Packaging Specification
Contains 0.22g acetylsalicylic acid, 0.15g phenacetin, 35mg caffeine
Validity Period
24 months
Manufacturer
Jilin Changbai Mountain Pharmaceutical Group Co., Ltd.
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Founded in:
1996-10-18 -
Address:
No. 1, High-tech Industrial Park, Hunjiang District, Baishan City, Jilin Province (Economic Development Zone) -
Tax NO.:
91220601717184476H -
Registered Funds:
100 million yuan -
Email: