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Aspirin

Aspirin structure

CAS No:
50-78-2
Formula:
C9H8O4
Chemical Name:
Aspirin
Synonyms:
Benzoic acid,2-(acetyloxy)-;Rhodine;Salicylic acid acetate;2-(Acetyloxy)benzoic acid;Aceticyl;Acetilum acidulatum;Acetophen;Acetosal;Acetosalic acid;Acetosalin;o-Acetoxybenzoic acid;2-Acetoxybenzoic acid;Acetylin;Acetylsal;Acidum acetylsalicylicum;Acylpyrin;Aspirin;Aspirine;Aspro;Asteric;A.S.A. Empirin;Helicon;Measurin;Salacetin;Salcetogen;Saletin;Xaxa;Acetylsalicylic acid;Asagran;Rhonal;Acenterine;SP 189;ASA;Duramax;Ecotrin;Entrophen;Enterosarine;Neuronika;Endydol;Acetisal;Colfarit;Acisal;Dolean pH 8;AC 5230;Acesal;Polopiryna;o-Carboxyphenyl acetate;Triple-sal;Rheumintabletten;Idragin;Yasta;Benaspir;Temperal;Bialpirina;2-Carboxyphenyl acetate;Globentyl;Novid;Globoid;O-Acetylsalicylic acid;Micristin;Acetysal;Acetard;Medisyl;Caprin;ECM;Empirin;Istopirin;o-(Acetyloxy)benzoic acid;Endosprin;Aspro Clear;Kapsazal;Aspropharm;Zorprin;Aspirina 03;Rhodine NC RP;Acesan;Miniasal;Aspirin Protect 100;Aspirin Protect 300;Melhoral;Claradin;Coricidin;Contrheuma Retard;Aspalon;Aspergum;Bialpirinia;Enterophen;Solpyron;Easprin;Darvon Compound;Extren;Gelprin;Nu-seals;Supac;Acetyonyl;Persistin;Acimetten;Coricidin D;Aspirdrops;Salycylacetylsalicylic acid;Ascriptin;Crystar;Ascoden 30;Asatard;Entericin;Albyl E;Adiro;Cardioaspirina;Ewin;Dominal;Toldex;NSC 27223;NSC 406186;Ascolong;Aspirin-Direkt;Asaflow;Trombyl;Magnecyl;Lysoprin (pharmaceutical);Salospir;Rhodine 2312;Astrix;Mycropyrin;Colsprin;Ecosprin;2349-94-2;11126-35-5;11126-37-7;26914-13-6;98201-60-6;2087491-38-9
Categories:
Cosmetic Ingredient > Exfoliating

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Description

Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.

Aspirin Basic Attributes

Molecular Weight：

180.15700

Exact Mass：

180.16

EC Number：

200-064-1

HScode：

3004909090

Characteristics

PSA：

63.60000

XLogP3：

1.31010

Appearance：

Acetylsalicylic acid appears as odorless white crystals or crystalline powder with a slightly bitter taste. (NTP, 1992)

Density：

1.40 g/cm³

Melting Point：

135 °C

Boiling Point：

197-200 °C @ Press: 7 Torr

Flash Point：

250ºC

Refractive Index：

1.551

Water Solubility：

H2O: 3.3 g/L (20 ºC)

Storage Conditions：

Store at RT.

Vapor Pressure：

Vapour pressure, Pa at 25°C: ~ 0.004

Toxicity：

LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart)

Flammability characteristics：

Combustible Powder; explosion hazard if dispersed in air.

Odor：

Odorless, but in moist air it is gradually hydrolyzed and acquires odor of acetic acid

PKA：

3.5None

Safety Information

Packing level：

III

Transport codes：

UN 1851

wgk germany：

hazard class code：

R22; R36/37/38

safety instructions：

S26-S36/37/39

RTECS Number：

VO0700000

Marks：

Storage features：

Well closed.

Stability/Shelf Life：

Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

Aspirin Use and Manufacturing

1. Antifungal
2. Axepim Cephalosporin antibiotic
3. Analgesic; antipyretic; anti-inflammatory; antithrombotic

Computed Properties

Molecular Weight:180.16
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:180.04225873
Monoisotopic Mass:180.04225873
Topological Polar Surface Area:63.6
Heavy Atom Count:13
Complexity:212
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetic acid

Acetone

Salicylic acid

Sulfuric acid

Downstream Products

Carbon dioxide

Acetic acid

Salicylic acid

Price Analysis

Make your Aspirin purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Aspirin prices .

Drug Function and Efficacy

Analgesic effect: It may have a central analgesic effect by inhibiting the synthesis of prostaglandins and other sensitive substances; Anti-inflammatory effect: It may inhibit the synthesis of prostaglandins or other inflammatory substances; Antipyretic effect: It may increase heat dissipation by acting on the hypothalamic temperature regulation center; Anti-rheumatic effect: In addition to antipyretic and analgesic, it mainly has an anti-inflammatory effect; Inhibitory effect on platelet aggregation: It prevents the formation of thromboxane A2 by inhibiting platelet prostaglandin cyclooxygenase.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound acetylsalicylic acid tablets
Ingredients	Acetylsalicylic acid.
Indication	Not yet clear.
Specifications	Aspirin 0.22g, phenacetin 0.15g, caffeine 35mg.
Manufacturer	TongHua Limin Pharmaceutical Co., Ltd.

Aspirin enteric-coated tablets
Ingredients	Main ingredient: Aspirin. Chemical name: 2-(acetoxy)benzoic acid Molecular weight: C9H8O4
Indication	This product may increase the effects of the following drugs: 1. Anticoagulants 2. The risk of gastrointestinal bleeding caused by the simultaneous use of drugs containing cortisone or cortisone analogs, or drinking alcohol at the same time.
Specifications	25mg*100s
Manufacturer	Huadong Medicine (Xi'an) Bodyguard Pharmaceutical Co., Ltd.

Aspirin Vitamin C Enteric Coated Tablets
Ingredients	Each tablet contains 250 mg of aspirin and 25 mg of vitamin C. Excipients include starch, magnesium stearate, acrylic resin II, acrylic resin III, diethyl phthalate, Tween 80, and ethanol.
Indication	1 This product should not be used with anticoagulants (such as dicoumarol, heparin) and thrombolytic drugs (streptokinase). 2 Antacids such as sodium bicarbonate can increase the excretion of this product in urine, causing a decrease in blood drug concentration, and should not be used together. 3 This product can increase gastrointestinal adverse reactions when used with glucocorticoids (such as dexamethasone, etc.). 4 This product can enhance the effects of oral hypoglycemic drugs and methotrexate, and should not be used together. 5 If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	Aspirin 0.25g, Vitamin C 25mg
Manufacturer	Harbin Taihua Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

ZYDUS LIFESCIENCES LTD

United States
Active
NOVACYL (THAILAND) CO., LTD.

Thailand
Active
NOVACYL

France
Active

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