Erythromycin Granules

This product belongs to the macrolide antibiotics, which is the dodecyl sulfate of erythromycin propionate. It has antibacterial activity against Staphylococcus, various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. This product is only effective against bacteria with active division.

Erythromycin estolate.

This product is a granule with flavoring agent; it has a fragrant smell and a sweet taste.

1 This product is used as an alternative to penicillin-allergic patients to treat the following infections: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococcus, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeriosis, etc. 2 Legionnaires' disease. 3 Mycoplasma pneumoniae pneumonia. 4 Chlamydia pneumoniae pneumonia.

Oral administration: adults 1-2 g per day divided into 3-4 times; children 20-30 mg/kg per day divided into 3-4 times according to body weight.

1. Patients with hepatotoxic reactions after taking this product are more common than those taking other erythromycin preparations. After taking the drug for several days or 1 to 2 weeks, patients may experience fatigue, nausea, vomiting, abdominal pain, rash, fever, etc. Jaundice may sometimes occur, and liver function tests show cholestasis, which can often be recovered after stopping the drug. 2. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, mouth and tongue pain, decreased appetite, etc., and their incidence is related to the size of the dose. 3. When a large dose (ge; 4g/day) is used, especially in patients with liver and kidney diseases or elderly patients, hearing loss may occur, which is mainly related to the high blood drug concentration (12mg/L), and most of them can be recovered after stopping the drug. 4. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 5. Others: Occasionally there are arrhythmias, oral or vaginal candidal infections.

It is contraindicated for patients who are allergic to erythromycin.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: 1. This product can enter the fetal circulation through the placenta, and the possibility of hepatotoxicity after taking this product increases for pregnant women, so it is not suitable for pregnant women. 2. A considerable amount of erythromycin enters breast milk, so breastfeeding should be stopped when using it for lactating women. Precautions for the elderly: Not yet clear.

1. This product can inhibit the metabolism of antiepileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations of the latter and toxic reactions. This product can inhibit the metabolism of the latter and prolong its duration of action when used in combination with alfentanil. This product can increase cardiac toxicity when used in combination with antihistamines such as astemizole or terfenadine, and can increase the latter's blood concentration and produce nephrotoxicity when used in combination with cyclosporine. 2. It has an antagonistic effect with chloramphenicol and lincosamides, and is not recommended for combined use. 3. This product is an antibacterial agent that can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as the treatment of meningitis, the two should not be used in combination. 4. Patients who have been taking warfarin for a long time can prolong the prothrombin time when using erythromycin, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used in combination, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5Except for dihydroxypropylphylline, the combination of this product with xanthines can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of combined use, and the reduction in aminophylline clearance is proportional to the serum peak value of this product. Therefore, the dose of xanthines should be adjusted during and after the combined treatment of the two. 6Combination with other hepatotoxic drugs may enhance hepatotoxicity. 7Combination of large doses of this product with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8When used in combination with lovastatin, its metabolism can be inhibited and blood concentrations can be increased, which may cause rhabdomyolysis. When used in combination with midazolam or triazolam, the clearance of both can be reduced and their effects can be enhanced.

Keep away from light and sealed.

75 mg (75,000 units) of erythromycin

24 months

Shanxi Aoer Pharmaceutical Co., Ltd.

• Founded in:

  2002-01-06

• Address:

  Linyi County High-tech Industrial Park

• Tax NO.:

  91140821734026250B

• Registered Funds:

  79 million yuan

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